N-(4-Fluorophenyl)pyridin-2(1H)-one

Base Information

Chemical Name:N-(4-Fluorophenyl)pyridin-2(1H)-one
CAS No.:60532-42-5
Molecular Formula:C₁₁H₈FNO
Molecular Weight:189.189
Hs Code.:
DSSTox Substance ID:DTXSID80475292
Wikidata:Q82305660
Mol file:60532-42-5.mol

Synonyms:N-(4-FLUOROPHENYL)PYRIDIN-2(1H)-ONE;60532-42-5;1-(4-fluorophenyl)pyridin-2-one;1-(4-fluorophenyl)pyridin-2(1H)-one;1-(4-fluorophenyl)-1,2-dihydropyridin-2-one;SCHEMBL142777;DTXSID80475292;AKOS006329454;FT-0668727

Suppliers and Price of N-(4-Fluorophenyl)pyridin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(4-Fluorophenyl)pyridin-2(1H)-one
50mg
$ 215.00

TRC
N-(4-Fluorophenyl)pyridin-2(1H)-one
25mg
$ 110.00

Medical Isotopes, Inc.
N-(4-Fluorophenyl)pyridin-2(1H)-one
25 mg
$ 860.00

American Custom Chemicals Corporation
N-(4-FLUOROPHENYL)PYRIDIN-2(1H)-ONE 95.00%
250MG
$ 1593.90

American Custom Chemicals Corporation
N-(4-FLUOROPHENYL)PYRIDIN-2(1H)-ONE 95.00%
25MG
$ 704.55

Total 5 raw suppliers

Chemical Property of N-(4-Fluorophenyl)pyridin-2(1H)-one

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:138-139oC
Boiling Point:341.697oC at 760 mmHg
Flash Point:160.453oC
PSA：22.00000
Density:1.27g/cm3
LogP:1.97660
Storage Temp.:-20°C Freezer
Solubility.:Chloroform, DMF, Methanol
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:189.058992041
Heavy Atom Count:14
Complexity:277

Purity/Quality:

97% ^*data from raw suppliers

N-(4-Fluorophenyl)pyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=O)N(C=C1)C2=CC=C(C=C2)F
Uses A metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes A metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes.

Technology Process of N-(4-Fluorophenyl)pyridin-2(1H)-one

There total 3 articles about N-(4-Fluorophenyl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 142-08-5,1199357-22-6
2-Pyridone

: di-(p-fluorophenyl)iodonium trifluoromethanesulfonate

: 60532-42-5
1-(4-fluorophenyl)pyridin-2(1H)-one

Guidance literature:: With N,N-diethylaniline; In fluorobenzene; at 85 ℃; for 16h; chemoselective reaction;
DOI:10.1039/d0sc02516j

Reference yield: 71.0%

: 23353-96-0
pyridin-2(3H)-one

: di-(p-fluorophenyl)iodonium trifluoromethanesulfonate

: 60532-42-5
1-(4-fluorophenyl)pyridin-2(1H)-one

: 1173294-78-4
2-(4-fluorophenoxy)pyridine

Guidance literature:: With caesium carbonate; In 1,2-dichloro-ethane; at 120 ℃;
DOI:10.1055/s-0036-1591884

Reference yield: 66.0%

: 142-08-5,1199357-22-6
2-Pyridone

: 352-34-1
4-fluoro-1-iodobenzene

: 60532-42-5
1-(4-fluorophenyl)pyridin-2(1H)-one

Guidance literature:: With copper (I) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 6h; Schlenk technique; Inert atmosphere;
DOI:10.1021/acs.joc.2c00428