1173294-78-4

Basic information

• Product Name: 2-(4-fluorophenoxy)pyridine
• Synonyms: 2-(4-fluorophenoxy)pyridine
• CAS NO: 1173294-78-4
• Molecular Weight: 189.189
• Mol File: 1173294-78-4.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenoxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenoxy)pyridine(1173294-78-4)
• EPA Substance Registry System: 2-(4-fluorophenoxy)pyridine(1173294-78-4)

Safety Data

• Hazardous Substances Data: 1173294-78-4(Hazardous Substances Data)

Upstream product

• 23353-96-0 pyridin-2(3H)-one 
• 142-08-5 2-Pyridone 
• 98-98-6 2-Picolinic acid 
• 371-41-5 4-Fluorophenol 
• 3902-84-9 potassium 2-oxo-2H-pyridin-1-ide 
• 109-04-6 2-bromo-pyridine 
• 109-09-1 2-chloropyridine 

Downstream Products

• 1173294-86-4 (5-fluoro-2-(pyridin-2-yloxy)phenyl)(phenyl)methanone 
• 362-47-0 (5-fluoro-2-hydroxyphenyl)(phenyl)methanone 
• 28396-55-6 2-(4-fluorophenyl)naphthalene 
• 1996-41-4 2-chloro-4-fluorophenol 
• 4280-40-4 4-(4-fluorophenyl)morpholine 
• 225916-39-2 2-(4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 214360-58-4 2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant articles and documents

Ruthenium-Catalyzed meta-CAr–H Bond Difluoroalkylation of 2-Phenoxypyridines

A ruthenium-catalyzed meta-selective CAr–H bond difluoroalkylation of 2-phenoxypyridine using 2-bromo-2,2-difluoroacetate has been developed. Mechanistic studies indicated that this difluoroalkylation might involve a radical process. Furthermore, a new method is reported for the synthesis of 2-(meta-difluoroalkylphenoxy)pyridine derivatives, which are present in many pharmaceuticals and other functional compounds.

A directing group-assisted ruthenium-catalyzed approach to access: Meta -nitrated phenols

meta-Selective C-H nitration of phenol derivatives was developed using a Ru-catalyzed σ-activation strategy. Cu(NO3)2·3H2O was employed as the nitrating source, whereas Ru3(CO)12 was found to be the most suitable metal catalyst for the protocol. Mechanistic studies suggested involvement of an ortho-CAr-H metal intermediate, which promoted meta-electrophilic aromatic substitution and silver-assisted free-radical pathway.

Substituent Effects of 2-Pyridones on Selective O-Arylation with Diaryliodonium Salts: Synthesis of 2-Aryloxypyridines under Transition-Metal-Free Conditions

An efficient transition-metal-free strategy to synthesize 2-aryloxypyridine derivatives has been developed by a selective O-arylation of 2-pyridones with diaryliodonium salts. The reaction was compatible with a series of functional groups for 2-pyridones and diaryliodonium salts such as halides, nitro, cyano, and ester groups. The substituents at the C6-position of 2-pyridones favored O-arylation products because of steric hindrance. The reaction was easily performed on a gram-scale and 6-chloro-2-pyridone was a good precursor to access various unsubstituted 2-aryloxypyridines by dehalogenation. A P2Y 1 lead compound analogue could be prepared in good yield over two steps.