2-(2-Pyridinyloxy)-2-methylpropionic acid

Base Information

Chemical Name:2-(2-Pyridinyloxy)-2-methylpropionic acid
CAS No.:605680-46-4
Molecular Formula:C9H11NO3
Molecular Weight:181.18900
Hs Code.:
DSSTox Substance ID:DTXSID00582639
Wikidata:Q82474122
Mol file:605680-46-4.mol

Synonyms:605680-46-4;2-(2-Pyridinyloxy)-2-methylpropionic acid;2-methyl-2-pyridin-2-yloxypropanoic acid;Propanoic acid, 2-methyl-2-(2-pyridinyloxy)-;2-Methyl-2-(2-pyridinyloxy)-Propanoicacid;SCHEMBL3368880;DTXSID00582639;2-Methyl-2-[(pyridin-2-yl)oxy]propanoic acid;A18971;2-METHYL-2-(PYRIDIN-2-YLOXY)PROPANOIC ACID

Suppliers and Price of 2-(2-Pyridinyloxy)-2-methylpropionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 2-(2-Pyridinyloxy)-2-methylpropionic acid

Chemical Property:

PSA：59.42000
LogP:1.32360
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:181.07389321
Heavy Atom Count:13
Complexity:191

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C(=O)O)OC1=CC=CC=N1

Technology Process of 2-(2-Pyridinyloxy)-2-methylpropionic acid

There total 4 articles about 2-(2-Pyridinyloxy)-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 922502-04-3
benzyl 2-(2-pyridyloxy)-2-methylpropionate

: 605680-46-4
2-(2-pyridyloxy)-2-methylpropionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃;
DOI:10.1021/jm060996+

Reference yield:

: 605680-44-2
benzyl 2-(2-pyridyloxy)propionate

: 605680-46-4
2-(2-pyridyloxy)-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / 2 h / -78 - 20 °C

2: 93 percent / H₂ / Pd/C / methanol / 20 °C

With hydrogen; potassium hexamethylsilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm060996+

Reference yield:

: 142-08-5
2-hydroxypyridin

: 605680-46-4
2-(2-pyridyloxy)-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: PPh₃; diethyl azodicarboxylate / CH₂Cl₂ / 4 h / 0 - 20 °C

2: potassium hexamethyldisilazide / tetrahydrofuran; toluene / 2 h / -78 - 20 °C

3: 93 percent / H₂ / Pd/C / methanol / 20 °C

With hydrogen; potassium hexamethylsilazane; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm060996+