(2E)-3-(2-METHOXY-5-METHYLPHENYL)ACRYLIC ACID

Base Information

• Chemical Name: (2E)-3-(2-METHOXY-5-METHYLPHENYL)ACRYLIC ACID
• CAS No.: 103986-76-1
• Molecular Formula: C11H12 O3
• Molecular Weight: 192.214
• Hs Code.: 2918990090
• Mol file: 103986-76-1.mol

Synonyms:Cinnamicacid, 2-methoxy-5-methyl- (6CI); 2-Methoxy-5-methylcinnamic acid;3-(2-Methoxy-5-[methyl]phenyl)acrylic acid

Chemical Property of (2E)-3-(2-METHOXY-5-METHYLPHENYL)ACRYLIC ACID

Chemical Property:

• Vapor Pressure: 3.53E-05mmHg at 25°C
• Boiling Point: 339.6°Cat760mmHg
• Flash Point: 132.8°C
• PSA: 46.53000
• Density: 1.162g/cm³
• LogP: 2.10140

Purity/Quality:

99% ^*data from raw suppliers

3-(2-Methoxy-5-methylphenyl)prop-2-enoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2E)-3-(2-METHOXY-5-METHYLPHENYL)ACRYLIC ACID

There total 10 articles about (2E)-3-(2-METHOXY-5-METHYLPHENYL)ACRYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

6-methylcoumarin (92-48-8) + dimethyl sulfate (77-78-1) → 3-(2'-methoxy-5-methylphenyl)prop-2-enoic acid (103986-76-1)

Guidance literature:

6-methylcoumarin; With sodium hydroxide; water; Heating;

dimethyl sulfate; In water; for 2.5h; Heating;

With hydrogenchloride; In water;

Reference yield:

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 2-methoxy-5-methylbenzaldehyde (7083-19-4) → 3-(2'-methoxy-5-methylphenyl)prop-2-enoic acid (103986-76-1)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; 2-methoxy-5-methylbenzaldehyde; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

With hydrogenchloride; sodium hydroxide; more than 3 stages;

Reference yield:

ethyl (E)-3-(2-methoxy-5-methylphenyl)acrylate (1194827-68-3) → (E)-3-(2-methoxy-5-methylphenyl)propenoic acid (103986-76-1)

Guidance literature:

ethyl (E)-3-(2-methoxy-5-methylphenyl)acrylate; With sodium hydroxide; In water;

With hydrogenchloride; In water;

upstream raw materials:

2-methoxy-5-methyl-cinnamic acid ethyl ester

diethoxyphosphoryl-acetic acid ethyl ester

2-methoxy-5-methylbenzaldehyde

6-methylcoumarin

Downstream raw materials:

3-(2'-methoxy-5-methylphenyl)propanoic acid

4-(2-Methoxy-5-methylphenyl)-6-methyl-3,4-dihydrocoumarin

(S)-3-(2-methoxy-5-methylphenyl)-3-phenylpropanal

(E)-3-(2-methoxy-5-methylphenyl)acrylaldehyde

Refernces

• 1、 -. "TETRAHYDROBENZOTHIOPHENE DERIVATIVES". Page/Page column 187. . Retrieved 2008/06/13.
• 2、 Kamat, Shrivallabh P.,Menezes, Jose C.,Siddhaye, Bhushan M.,Paknikar, Shashikumar K.. "Facile syntheses of 4-hydroxy-7-methyl-1-indanone, isolated from cyanobacterium Nostoc commune". experimental part. p. 1597 - 1599. Retrieved 2009/04/07.