1-(Isocyano(tosyl)methyl)-2-methoxybenzene

Base Information

Chemical Name:1-(Isocyano(tosyl)methyl)-2-methoxybenzene
CAS No.:263389-53-3
Molecular Formula:C16H15NO3S
Molecular Weight:301.366
Hs Code.:2934999090
DSSTox Substance ID:DTXSID30377999
Nikkaji Number:J1.286.174E
Mol file:263389-53-3.mol

Synonyms:263389-53-3;1-(isocyano(tosyl)methyl)-2-methoxybenzene;a-Tosyl-(2-methoxybenzyl) isocyanide;ISOCYANO(2-METHOXYPHENYL)METHYL-4-METHYLPHENYL SULFONE;1-[isocyano-(4-methylphenyl)sulfonylmethyl]-2-methoxybenzene;a-Tosyl-(2-methoxybenzyl)isocyanide;1-[ISOCYANO[(4-METHYLPHENYL)SULFONYL]METHYL]-2-METHOXYBENZENE;SCHEMBL457261;[1-(2-METHOXYPHENYL)-1-TOSYL]METHYL ISOCYANIDE;Isocyano(2-methoxyphenyl)methyl-4-methylphenyl sulphone;DTXSID30377999;BTXVFJYPHAIAST-UHFFFAOYSA-N;AKOS005257478;AB18989;AS-40495;A5236;FT-0604145;alpha-(p-Tolylsulfonyl)-2-methoxybenzyl isocyanide;Isocyano(2-methoxyphenyl)methyl-4-methylphenylsulfone;1-[Isocyano(4-methylbenzene-1-sulfonyl)methyl]-2-methoxybenzene;COC1=C(C=CC=C1)C([N+]#[C-])S(=O)(=O)C1=CC=C(C)C=C1

Suppliers and Price of 1-(Isocyano(tosyl)methyl)-2-methoxybenzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
Isocyano(2-methoxyphenyl)methyl-4-methylphenyl sulfone
500 mg
$ 421.00

SynChem
a-Tosyl-(2-methoxybenzyl) isocyanide 95+%
1 g
$ 150.00

SynChem
a-Tosyl-(2-methoxybenzyl) isocyanide 95+%
5 g
$ 600.00

SynChem
a-Tosyl-(2-methoxybenzyl) isocyanide 95+%
10 g
$ 900.00

J&W Pharmlab
[1-(2-Methoxyphenyl)-1-tosyl]methylisocyanide 96%
5g
$ 698.00

American Custom Chemicals Corporation
ISOCYANO(2-METHOXYPHENYL)METHYL-4-METHYLPHENYL SULFONE 95.00%
500MG
$ 960.25

AK Scientific
1-(Isocyano(tosyl)methyl)-2-methoxybenzene
1g
$ 411.00

aablocks
Isocyano(2-methoxyphenyl)methyl-4-methylphenylsulfone 98%
5g
$ 1334.00

aablocks
Isocyano(2-methoxyphenyl)methyl-4-methylphenylsulfone 98%
1g
$ 356.00

aablocks
Isocyano(2-methoxyphenyl)methyl-4-methylphenylsulfone 98%
250mg
$ 120.00

Total 13 raw suppliers

Chemical Property of 1-(Isocyano(tosyl)methyl)-2-methoxybenzene

Chemical Property:

PSA：51.75000
LogP:3.70690
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:301.07726451
Heavy Atom Count:21
Complexity:479

Purity/Quality:

97% ^*data from raw suppliers

Isocyano(2-methoxyphenyl)methyl-4-methylphenyl sulfone ^*data from reagent suppliers

Safty Information:

Pictogram(s): C
Hazard Codes:C

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)C(C2=CC=CC=C2OC)[N+]#[C-]

Technology Process of 1-(Isocyano(tosyl)methyl)-2-methoxybenzene

There total 5 articles about 1-(Isocyano(tosyl)methyl)-2-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1006877-05-9
N-[2-methoxyphenyl(toluene-4-sulfonyl)methyl]formamide

: 263389-53-3
(2-methoxyphenyl)[(4-methylphenyl)sulfonyl]methanisocyanide

Guidance literature:: With triethylamine; trichlorophosphate; In tetrahydrofuran; at -10 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c5md00317b

Reference yield:

: 536-57-2
p-toluene sulfinic acid

: 263389-53-3
(2-methoxyphenyl)[(4-methylphenyl)sulfonyl]methanisocyanide

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃; triethylamine

With triethylamine; trichlorophosphate;
DOI:10.1016/j.bmcl.2005.11.102

Reference yield:

: 824-79-3
sodium 4-methylbenzenesulfinate

: 263389-53-3
(2-methoxyphenyl)[(4-methylphenyl)sulfonyl]methanisocyanide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water; tert-butyl methyl ether / 20 °C

2: acetonitrile; toluene / 16 h / 55 °C

3: trichlorophosphate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

With hydrogenchloride; triethylamine; trichlorophosphate; In tetrahydrofuran; tert-butyl methyl ether; water; toluene; acetonitrile;
DOI:10.1039/c9ob00660e