Hexahydro-1H-furo[3,4-c]pyrrole

Base Information

• Chemical Name: Hexahydro-1H-furo[3,4-c]pyrrole
• CAS No.: 60889-32-9
• Molecular Formula: C6H11NO
• Molecular Weight: 113.159
• Hs Code.: 2934999090
• Mol file: 60889-32-9.mol

Synonyms:Hexahydro-1H-furo[3,4-c]pyrrole hydrochloride;hexahydro-furo[3,4-c]pyrrole;HEXAHYDRO-1H-FURO[3,4-C]PYRROLE HCL;Hexahydro-1H-furo<3,4-c>pyrrol;hexahydro-1H-furo(3,4-c) pyrrole;

Chemical Property of Hexahydro-1H-furo[3,4-c]pyrrole

Chemical Property:

• Boiling Point: 177.9±33.0 °C(Predicted)
• PKA: 10.54±0.20(Predicted)
• PSA: 21.26000
• Density: 1.028±0.06 g/cm3(Predicted)
• LogP: 0.98300

Purity/Quality:

99%, ^*data from raw suppliers

Hexahydro-1H-furo[3,4-c]pyrrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hexahydro-1H-furo[3,4-c]pyrrole

There total 4 articles about Hexahydro-1H-furo[3,4-c]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-benzylhexahydro-1H-furo[3,4-c]pyrrole (60889-30-7) → hexahydro-1H-furo(3,4-c)-pyrrole (60889-32-9)

Guidance literature:

With hydrogen; palladium(II) hydroxide; In ethanol; at 20 ℃; for 12h;

Reference yield:

1-benzyl-pyrrolidine-3,4-dicarboxylic acid dimethyl ester (607362-87-8) → hexahydro-1H-furo(3,4-c)-pyrrole (60889-32-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere

2.1: p-toluenesulfonyl chloride; dmap; triethylamine / toluene / 12 h / 20 °C / Inert atmosphere

2.2: 4 h / Reflux

3.1: hydrogen; palladium(II) hydroxide / ethanol / 12 h / 20 °C

With dmap; lithium aluminium tetrahydride; hydrogen; palladium(II) hydroxide; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; ethanol; toluene;

Reference yield:

(1-benzylpyrrolidine-3,4-diyl)dimethanol (1256106-48-5,1345831-65-3) → hexahydro-1H-furo(3,4-c)-pyrrole (60889-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: p-toluenesulfonyl chloride; dmap; triethylamine / toluene / 12 h / 20 °C / Inert atmosphere

1.2: 4 h / Reflux

2.1: hydrogen; palladium(II) hydroxide / ethanol / 12 h / 20 °C

With dmap; hydrogen; palladium(II) hydroxide; triethylamine; p-toluenesulfonyl chloride; In ethanol; toluene;

upstream raw materials:

1-benzyl-pyrrolidine-3,4-dicarboxylic acid dimethyl ester

(1-benzylpyrrolidine-3,4-diyl)dimethanol

5-benzylhexahydro-1H-furo[3,4-c]pyrrole

Downstream raw materials:

5-benzenesulfonyl-hexahydro-furo[3,4-c]pyrrole

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