Technology Process of 1H-Isoindol-1-one, 3-(4-chlorophenyl)-2,3-dihydro-3-hydroxy-2-methyl-
There total 5 articles about 1H-Isoindol-1-one, 3-(4-chlorophenyl)-2,3-dihydro-3-hydroxy-2-methyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: phosphorus pentoxide / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hexamethyldisilazane; palladium diacetate; nixantphos / 1,4-dioxane / 0.08 h / 20 °C / Inert atmosphere; Sealed tube
2.2: 4 h / 50 °C
2.3: air / 2 h / 20 °C
With
phosphorus pentoxide; palladium diacetate; sodium hexamethyldisilazane; nixantphos;
In
1,4-dioxane; dichloromethane;
DOI:10.1002/adsc.201600654
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrahydrofuran; acetone; water / 2 h / 0 - 20 °C
2.1: phosphorus pentoxide / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere
3.1: sodium hexamethyldisilazane; palladium diacetate; nixantphos / 1,4-dioxane / 0.08 h / 20 °C / Inert atmosphere; Sealed tube
3.2: 4 h / 50 °C
3.3: air / 2 h / 20 °C
With
phosphorus pentoxide; palladium diacetate; sodium hexamethyldisilazane; nixantphos;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone;
DOI:10.1002/adsc.201600654
- Guidance literature:
-
Multi-step reaction with 2 steps
1: thionyl chloride; dimethylformamide
2: water; methanol / Erhitzen des Methylamin-Salzes der 2-<4-Chlor-benzoyl>-benzoesaeure auf 180grad
With
methanol; thionyl chloride; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19590420344