6-fluoro-7-(1-piperazinyl)-1-(2'-phenyl-1'-cyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Base Information

Chemical Name:6-fluoro-7-(1-piperazinyl)-1-(2'-phenyl-1'-cyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
CAS No.:103531-48-2
Molecular Formula:C23H22 F N3 O3
Molecular Weight:407.444
Hs Code.:
Mol file:103531-48-2.mol

Synonyms:6-fluoro-7-(1-piperazinyl)-1-(2’-phenyl-1’-cyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Suppliers and Price of 6-fluoro-7-(1-piperazinyl)-1-(2'-phenyl-1'-cyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-fluoro-7-(1-piperazinyl)-1-(2'-phenyl-1'-cyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Chemical Property:

Boiling Point:653.6°Cat760mmHg
Flash Point:349.1°C
PSA：74.57000
Density:1.4g/cm³
LogP:3.37080

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-fluoro-7-(1-piperazinyl)-1-(2'-phenyl-1'-cyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

There total 8 articles about 6-fluoro-7-(1-piperazinyl)-1-(2'-phenyl-1'-cyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 103531-46-0
(+)-7-<4-(ethoxycarbonyl)piperazino>-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl piperazinecarboxylate salt

: 103531-48-2
(+)-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-7-piperazino-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; for 48h; Heating;
DOI:10.1021/jm00160a042

Reference yield:

: 95-62-5,155-09-9,3721-26-4,3721-28-6,13531-35-6,24873-95-8,69684-88-4,69684-89-5,54-97-7
(1R,2S)-1-amino-2-phenylcyclopropane

: 103531-48-2
(+)-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-7-piperazino-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: CH₂Cl₂ / 0.5 h / Ambient temperature

2: 79 percent / NaH / tetrahydrofuran / 4 h / 70 °C

3: 87 percent / KOH / tetrahydrofuran; H₂O / 1.5 h / 65 - 70 °C

4: 90 percent / various solvent(s) / 18 h / 100 - 110 °C

5: 42 percent / 10percent aq. KOH / ethanol / 48 h / Heating

With potassium hydroxide; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm00160a042

Reference yield:

: 155-09-9
trans-2-phenylcyclopropylamine

: 103531-48-2
(+)-6-fluoro-1-<(1'R,2'S)-2'-phenylcyclopropyl>-7-piperazino-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

2: CH₂Cl₂ / 0.5 h / Ambient temperature

3: 79 percent / NaH / tetrahydrofuran / 4 h / 70 °C

4: 87 percent / KOH / tetrahydrofuran; H₂O / 1.5 h / 65 - 70 °C

5: 90 percent / various solvent(s) / 18 h / 100 - 110 °C

6: 42 percent / 10percent aq. KOH / ethanol / 48 h / Heating

With potassium hydroxide; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm00160a042