Ethyl 2,4-dichloro-5-fluorobenzoylacetate

Base Information

Chemical Name:Ethyl 2,4-dichloro-5-fluorobenzoylacetate
CAS No.:86483-51-4
Molecular Formula:C11H9Cl2FO3
Molecular Weight:279.095
Hs Code.:2918300090
DSSTox Substance ID:DTXSID40378992
Wikidata:Q82168627
Mol file:86483-51-4.mol

Synonyms:86483-51-4;Ethyl 2,4-dichloro-5-fluorobenzoylacetate;ethyl 3-(2,4-dichloro-5-fluorophenyl)-3-oxopropanoate;ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate;ETHYL2,4-DICHLORO-5-FLUOROBENZOYLACETATE;SCHEMBL4714980;DTXSID40378992;POKPUCWXUHWGMX-UHFFFAOYSA-N;3-(2,4-dichloro-5-fluoro-phenyl)-3-oxo-propionic acid ethyl ester;AKOS009157397;ethyl 2,4-dichloro-5-fluoro-benzoylacetate;AM20041264;CS-0361473;Ethyl (2,4-dichloro-5-fluorobenzoyl)acetate;FT-0654163;ethyl 2-(2,4-dichloro-5-fluorobenzoyl)acetate;A841683;ethyl 3-(2,4-dichloro-5-fluoro-phenyl)-3-oxo-propanoate;3-(2,4-dichloro-5-fluorophenyl)-3-oxopropanoic acid ethyl ester

Suppliers and Price of Ethyl 2,4-dichloro-5-fluorobenzoylacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
ETHYL(2,4-DICHLORO-5-FLUOROBENZOYL)ACETATE 95
1000g
$ 3536.00

American Custom Chemicals Corporation
ETHYL 2,4-DICHLORO-5-FLUOROBENZOYLACETATE 95.00%
5G
$ 909.56

Alichem
Ethyl3-(2,4-dichloro-5-fluorophenyl)-3-oxopropanoate
1g
$ 321.44

Acrotein
Ethyl(2,4-dichloro-5-fluorobenzoyl)acetate 97%
0.5g
$ 330.00

Acrotein
Ethyl(2,4-dichloro-5-fluorobenzoyl)acetate 97%
0.25g
$ 220.00

Total 38 raw suppliers

Chemical Property of Ethyl 2,4-dichloro-5-fluorobenzoylacetate

Chemical Property:

Vapor Pressure:0.000177mmHg at 25°C
Refractive Index:1.523
Boiling Point:329.5 °C at 760 mmHg
Flash Point:127.6 °C
PSA：43.37000
Density:1.381 g/cm³
LogP:3.26840
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:277.9912777
Heavy Atom Count:17
Complexity:298

Purity/Quality:

97% ^*data from raw suppliers

ETHYL(2,4-DICHLORO-5-FLUOROBENZOYL)ACETATE 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi, F
Hazard Codes:Xi,F

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC(=O)C1=CC(=C(C=C1Cl)Cl)F

Technology Process of Ethyl 2,4-dichloro-5-fluorobenzoylacetate

There total 5 articles about Ethyl 2,4-dichloro-5-fluorobenzoylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 105-58-8,76619-83-5
Diethyl carbonate

: 86483-51-4
ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate

Guidance literature:: With sodium hydride; at 80 ℃; for 1.5h;
DOI:10.1002/jhet.5570220421 DOI:10.1021/jm00149a003

Reference yield:

: 86393-34-2
2,4-dichloro-5-fluorobenzoyl chloride

: 86483-51-4
ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: Mg/ethanol, CCl₄ / ethanol; toluene / 1.) 0 to -5 deg C, 2.) 12 h, room temperature

2: p-toluenesulfonic acid / H₂O / 5 h / Heating

With tetrachloromethane; ethanol; toluene-4-sulfonic acid; magnesium; In ethanol; water; toluene;