2-benzoyl-1-{4-nitrobenzyl}-1,2-dihydro-1-isoquinolinecarbonitrile

Base Information

Chemical Name:2-benzoyl-1-{4-nitrobenzyl}-1,2-dihydro-1-isoquinolinecarbonitrile
CAS No.:61010-36-4
Molecular Formula:C24H17N3O3
Molecular Weight:395.41000
Hs Code.:

Synonyms:2-Benzoyl-1-(4-nitro-benzyl)-1,2-dihydro-isoquinoline-1-carbonitrile;2-Benzoyl-1-(4-nitrobenzyl)-1,2-dihydroisochinaldonitril;1-(4-Nitro-benzyl)-2-benzoyl-1,2-dihydro-isochinolin-1-carbonitril;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-benzoyl-1-{4-nitrobenzyl}-1,2-dihydro-1-isoquinolinecarbonitrile

Chemical Property:

PSA：89.92000
LogP:5.14418

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-benzoyl-1-{4-nitrobenzyl}-1,2-dihydro-1-isoquinolinecarbonitrile

There total 4 articles about 2-benzoyl-1-{4-nitrobenzyl}-1,2-dihydro-1-isoquinolinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 844-25-7,55839-33-3
2-benzoyl-1-cyano-1,2-dihydroisoquinoline

: 100-14-1
4-nitrobenzyl chloride

: 61010-36-4
2-benzoyl-1-(4-nitro-benzyl)-1,2-dihydro-isoquinoline-1-carbonitrile

Guidance literature:: With sodium hydroxide; cetyltrimethylammonim bromide; In dichloromethane; for 0.416667h; Ambient temperature; Irradiation; ultrasound sonication;

Reference yield: 50.0%

: 844-25-7,55839-33-3
2-benzoyl-1-cyano-1,2-dihydroisoquinoline

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 61010-36-4
2-benzoyl-1-(4-nitro-benzyl)-1,2-dihydro-isoquinoline-1-carbonitrile

Guidance literature:: With sodium hydroxide; cetyltrimethylammonim bromide; In dichloromethane; for 0.416667h; Ambient temperature; ultrasound sonication;

Reference yield:

: 119-65-3
isoquinoline

: 61010-36-4
2-benzoyl-1-(4-nitro-benzyl)-1,2-dihydro-isoquinoline-1-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / triethylbenzylammonmium chloride / CH₂Cl₂; H₂O / 0.33 h / Irradiation; ultrasound sonication

2: 76 percent / 50percent aq. NaOH / cetyltrimethylammonium bromide / CH₂Cl₂ / 0.42 h / Ambient temperature; Irradiation; ultrasound sonication

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; cetyltrimethylammonim bromide; In dichloromethane; water;