100-14-1

Basic information

• Product Name: 4-Nitrobenzyl chloride
• Synonyms: alpha-chloro-p-nitro-toluen;alpha-chloro-p-nitrotoluene[qr];Benzene, 1-(chloromethyl)-4-nitro-;benzene,1-(chloromethyl)-4-nitro-[qr];benzylchloride,4-nitro[qr];p-(Chloromethyl)nitrobenzene;p-nitrobenzylchloride[qr];Toluene, alpha-chloro-p-nitro
• CAS NO: 100-14-1
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58
• EINECS: 202-822-7
• Product Categories: Aromatic Halides (substituted)
• Mol File: 100-14-1.mol
• Article Data: 90

Chemical Properties

• Melting Point: 71 °C
• Boiling Point: 112 °C (0.6 mmHg)
• Flash Point: 130.709 °C
• Appearance: Light yellow/Crystalline Needles or Powder
• Density: 1.3246 (rough estimate)
• Vapor Pressure: 0.0995mmHg at 25°C
• Refractive Index: 1.5647 (estimate)
• Solubility: chloroform: soluble50mg/mL, clear to very slightly hazy, faintly
• Stability: Stable. Incompatible with strong oxidizing agents, bases, amines, moisture, alcohols. Corrodes steel. Reacts slowly with water.
• BRN: 387187
• CAS DataBase Reference: 4-Nitrobenzyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitrobenzyl chloride(100-14-1)
• EPA Substance Registry System: 4-Nitrobenzyl chloride(100-14-1)

Safety Data

• Hazard Codes: C
• Statements: 22-34-36
• Safety Statements: 26-36/37/39-45-27
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• RTECS: XS9093000
• F: 4.8-19-21
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 100-14-1(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 100-14-1 differently. You can refer to the following data:
1. white to light yellow crystal powde
2. Benzene, 1-(chloromethyl)-4-nitro-, is a crystalline solid.

Uses

4-Nitrobenzyl chloride was used to prepare unsymmetrically N,N′-bis(substituted) 4,13-diaza-18-crown-6-ether derivatives.

Definition

ChEBI: A C-nitro compound that is nitrobenzene in which the hydrogen at position 4 is replaced by a chloromethyl group.

General Description

Solid.

Air & Water Reactions

May react slowly with water.

Reactivity Profile

Incompatible with sodium hydroxide. [EPA, 1998]. A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.

Health Hazard

Poisonous if swallowed or dust is inhaled.

Fire Hazard

Incompatible with sodium hydroxide.

Potential Exposure

A chloronitrobenzene compound, used in organic synthesis.

Shipping

UN3261 Corrosive solid, acidic, organic, n.o.s., Hazard class: 8; Labels: 8—Corrosive material, Technical Name Required. UN1578 Chloronitrobenzenes, solid or liquid, Hazard Class: 6.1; Labels: 6.1—Poisonous materials.

Purification Methods

Crystallise the chloride from CCl4, dry diethyl ether, or n-heptane, and dry it under vacuum. IRRITANT.[Beilstein 5 IV 856.]

Incompatibilities

Can react with sulfuric acid. Keep away from oxidizers, amines, bases: sodium hydroxide, and potassium hydroxide; may cause fire and explosions. Incompatible with strong oxidizing and reducing agents such as hydrides, certain amines, nitrides, azo/diazo compounds, alkali metals (potassium), and epoxides. Corrodes steel, some plastics and human tissue.

InChI:InChI=1/C7H6ClNO2/c8-5-6-2-1-3-7(4-6)9(10)11/h1-4H,5H2

Synthetic route

4-nitrobenzyl chloride (619-73-8) → 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With indium(III) chloride; dimethylmonochlorosilane; benzil In dichloromethane at 20℃; for 24h;	97%
With Ph3P(+)-N(CO2Et)-N(-)-CO2Et; N-methoxylamine hydrochloride In tetrahydrofuran at 0℃; for 0.0833333h;	95%
Stage #1: 4-nitrobenzyl chloride With diisopropyl-carbodiimide; copper(l) chloride In tetrahydrofuran at 100℃; for 0.0833333h; microwave irradiation; Stage #2: With acetyl chloride In tetrahydrofuran at 150℃; for 0.0833333h; microwave irradiation; Further stages.;	95%

benzyl chloride (100-44-7) → 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With sulfuric acid; silica gel; tetramethylammonium nitrate for 0.0333333h;	95%
With sulfuric acid; nitric acid In tetrachloromethane at 10℃; for 2h;	82.4%
With sulfuric acid; nitric acid at 0 - 20℃; for 2h;	45%

4-nitrobenzaldehdye (555-16-8) → 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With dichloromethylsilane; iron(III) chloride In 1,2-dimethoxyethane for 4h; Heating;	95%
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / ethanol / 0 - 20 °C / Inert atmosphere 2: thionyl chloride / Reflux View Scheme

4-nitrobenzyl chloride (619-73-8) + acetyl chloride (75-36-5) → 4-nitrobenzyl acetate (619-90-9) + 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With 2,3-diethyl-2-cyclopropen-1-one In tert-butyl methyl ether at 20℃; for 4h;	A n/a B 90%

2-(2-tert-butyldimethylsiloxyethyl)-4H-benzo[1,4]oxazin-3-one (191097-22-0) → 3,4-Dihydro-2-(2-hydroxyethyl)-4-(4-nitrobenzyl)-3-oxo-2H-1,4-benzoxazine (191096-97-6) + 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
	A n/a B 89%

4-nitrobenzyl trimethylsilyl ether (14856-73-6) → 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With 4-aminophenyl diphenylphosphinite; N-chloro-succinimide In dichloromethane for 3h; Heating;	87%

2-(4-nitrobenzyloxy)tetrahydro-2H-pyran (18483-99-3) → 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With 4-aminophenyl diphenylphosphinite; N-chloro-succinimide In dichloromethane for 5h; Heating;	85%

4-nitrobenzeneacetic acid (104-03-0) → 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With tert-butylhypochlorite; Ag(Phen)2OTf In acetonitrile at 20℃; for 26h; Inert atmosphere;	85%

1-methyl-4-nitrobenzene (99-99-0) → 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With hydrogenchloride; potassium chloride; tetrabutyl-ammonium chloride In water at 20℃; Irradiation; Green chemistry;	82%
With N-chloro-succinimide; N-hydroxyphthalimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 80℃; for 16h; Time; Sealed tube; Inert atmosphere;	67%
With Oxone; sodium chloride In chloroform; water at 20℃; for 18h; Solvent; Sealed tube; Irradiation;	62%

dichloromethane (75-09-2) + nitrobenzene (98-95-3) → 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
Stage #1: dichloromethane With n-butyllithium In tetrahydrofuran; hexane at -100℃; for 0.333333h; Inert atmosphere; Stage #2: nitrobenzene With N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran; hexane at -100℃; for 6h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; hexane; water at -100 - 20℃; Inert atmosphere;	71%

4-nitrobenzyl chloride (619-73-8) + 4-nitro-benzoyl chloride (122-04-3) → 4'-(nitrobenzyl) 4-nitrobenzoate (3481-11-6) + 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With N,N-dimethyl-formamide In dichloromethane at 20℃; for 12h;	A n/a B 57%

4-nitrobenzyl chloride (619-73-8) → 4-nitrobenzaldehdye (555-16-8) + 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With 2-chloro-1,3-dimethylimidazolinium chloride; dimethyl sulfoxide; triethylamine In dichloromethane at 20℃; Chlorination;	A 13% B 43%

styrene (292638-84-7) + (4-nitrophenyl)methanesulfonyl chloride (4025-75-6) → 4-nitrobenzyl chloride (100-14-1) + 1-(2-Chloro-2-phenyl-ethanesulfonylmethyl)-4-nitro-benzene

Conditions	Yield
dichlorotris(triphenylphosphine)ruthenium(II) at 80℃; for 72h;	A 34% B 9%

4-nitro-benzoic acid (62-23-7) → 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With gallium(III) trichloride; Hexamethyldisiloxane; copper dichloride In 1,2-dichloro-ethane at 20℃; for 5h; Sealed tube; Inert atmosphere;	23%

1-methyl-4-nitrobenzene (99-99-0) + hexabromobenzene (87-82-1) → 4-nitrobenzyl chloride (100-14-1) + 1-bromomethyl-4-nitro-benzene (100-11-8)

Conditions	Yield
at 200℃; Einleiten von Chlor;

4-nitrobenzyl fluoride (500-11-8) → 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With 1,4-dioxane; hydrogenchloride

benzimidic acid-(4-nitro-benzyl ester); hydrochloride → benzamide (55-21-0) + 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
at 60℃; Rate constant;

nitro acetate (591-09-3) + benzyl chloride (100-44-7) → 4-nitrobenzyl chloride (100-14-1) + 2-nitrobenzyl chloride (612-23-7)

benzyl chloride (100-44-7) → 4-nitrobenzyl chloride (100-14-1) + 2-nitrobenzyl chloride (612-23-7)

Conditions	Yield
With nitric acid
With sulfuric acid; nitric acid at 5 - 10℃;
With nitric acid; acetic anhydride at 30℃;

4-nitrobenzyl iodide (3145-86-6) → 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With tributyltin chloride In benzene at 50℃; Thermodynamic data; Equilibrium constant;	38 % Spectr.
With chloride In acetonitrile at 25℃; Rate constant; Equilibrium constant; other nucleophiles: Br(-);

4-nitrobenzaldehdye (555-16-8) → bis(p-nitrobenzyl)ether (56679-04-0) + 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With chloro-trimethyl-silane; thionyl chloride; 1,1,3,3-Tetramethyldisiloxane; zinc(II) iodide 1.) chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane, thionyl chloride, ZnI2, -70 deg C, 1 h; 2.) DMF, reflux, 2 h; Yield given. Multistep reaction. Yields of byproduct given;

N-chloro-S-(p-nitrobenzyl)-S-phenylsulfoximide (85313-83-3) → 4-nitrobenzyl chloride (100-14-1) + S-(p-nitrobenzyl)-S-phenylsulfoximide (85313-79-7)

Conditions	Yield
In ethanol; chloroform for 24h; Ambient temperature;

3-chloro-3-(p-nitrophenyl)diazirine (39184-67-3) → 4-nitrobenzaldehdye (555-16-8) + 4-nitrobenzyl chloride (100-14-1) + 4-nitro-benzoyl chloride (122-04-3)

Conditions	Yield
With oxygen In 2,2,4-trimethylpentane Product distribution; Mechanism; Ambient temperature; Irradiation;

4-nitrobenzyl selenocyanate (83293-39-4) → 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
With chloride In acetonitrile at 25℃; Rate constant; Equilibrium constant; other nucleophiles: NCS(-), Br(-);

1-(1-Chloro-2,2,2-trifluoro-ethyl)-3-fluoro-benzene (81577-12-0) + C7H6NO2(1+) → C8H5F4(1+) (128408-34-4) + 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
at 69.85℃; Thermodynamic data; chloride-transfer;

1-Chloro-3-(1-chloro-2,2,2-trifluoro-ethyl)-benzene (81577-14-2) + C7H6NO2(1+) → C8H5ClF3(1+) (128408-35-5) + 4-nitrobenzyl chloride (100-14-1)

Conditions	Yield
at 69.85℃; Thermodynamic data; chloride-transfer;

1,1-dichloro-1λ4-benz[c][1,2]oxathiol-3-one (66650-27-9) + 4-nitrobenzyl chloride (619-73-8) + diethyl ether (60-29-7) → 4-nitrobenzyl chloride (100-14-1) + o-carboxy-benzenesulfinic acid-<4-nitro-benzyl ester>

benzyl chloride (100-44-7) → 4-nitrobenzyl chloride (100-14-1) + o-nitro-benzyl chloride ; m-nitro-benzyl chloride

Conditions	Yield
With nitric acid

nitric acid (7697-37-2) + benzyl chloride (100-44-7) → 4-nitrobenzyl chloride (100-14-1) + 2-nitrobenzyl chloride (612-23-7) + 3-Nitrobenzyl chloride (619-23-8)

piperidine (110-89-4) + 4-nitrobenzyl chloride (100-14-1) → 1-(4-nitrobenzyl)piperidine (59507-44-7)

Conditions	Yield
In tetrahydrofuran at 20℃; benzylation;	100%
With potassium carbonate In acetonitrile for 16h; Heating / reflux;	70%
With ethanol

4-nitrobenzyl chloride (100-14-1) + 3-amino propanoic acid (107-95-9) → N-4-nitrobenzyl-β-alanine (294201-15-3)

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 20h;	100%

1-carbomethoxy-3,5-dihydroxybenzene (2150-44-9) + 4-nitrobenzyl chloride (100-14-1) → C22H18N2O8

Conditions	Yield
With potassium carbonate In acetone Reflux;	100%

2,4,6-trimethyl-[1,3,5]triazinane (638-14-2) + 4-nitrobenzyl chloride (100-14-1) → tris-(4-nitrobenzyl)amine (64309-88-2)

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile for 2h; Reflux;	100%

pyrrolidine (123-75-1) + 4-nitrobenzyl chloride (100-14-1) → 1-(4-nitro-benzyl)-pyrrolidine (133851-67-9)

Conditions	Yield
In tetrahydrofuran at 20℃; benzylation;	99%
In ethanol; water for 1h; Heating;	84%
With potassium carbonate In acetone for 46h; Heating;	75%

4-nitrobenzyl chloride (100-14-1) + dimethyl amine (124-40-3) → 4-(N,N-dimethylaminomethyl)nitrobenzene (15184-96-0)

Conditions	Yield
In water; 4-methyl-2-pentanone at 20 - 35℃;	99%
With ethanol at 100℃;
In diethyl ether

morpholine (110-91-8) + 4-nitrobenzyl chloride (100-14-1) → 4-(4-nitrobenzyl)morpholine (6425-46-3)

Conditions	Yield
In tetrahydrofuran at 20℃; benzylation;	99%
With potassium carbonate In xylene for 1h; Heating;	59%
With triethylamine In dichloromethane at 20℃;
With sodium carbonate In chloroform at 65℃; for 18h;	40.4 g
In toluene at 90℃; for 5h;

4-nitrobenzyl chloride (100-14-1) → 1-methyl-4-nitrobenzene (99-99-0)

Conditions	Yield
With sodium tetrahydroborate; cetyltributylphosphonium bromide In water; toluene at 40℃; for 0h; Product distribution;	99%
With phosphonic Acid; iodine In benzene at 100℃; for 36h; Inert atmosphere;	42%
With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) In toluene for 3h; Mechanism; Irradiation;	24%

1-(2-Methoxyphenyl)piperazine (35386-24-4) + 4-nitrobenzyl chloride (100-14-1) → 1-(4-nitrobenzyl)-4-(2-methoxyphenyl)piperazine (270062-75-4)

Conditions	Yield
With silica gel for 0.0833333h; Alkylation; Microwave irradiation;	99%
With potassium carbonate In butanone at 80℃; for 24h;	89%

1-(4-Nitrophenyl)piperazine (6269-89-2) + 4-nitrobenzyl chloride (100-14-1) → 1-(4-nitro-benzyl)-4-(4-nitro-phenyl)-piperazine

Conditions	Yield
With silica gel for 0.0833333h; Alkylation; Microwave irradiation;	99%

4-nitrobenzyl chloride (100-14-1) + phenylboronic acid (98-80-6) → 4-benzyl-1-nitrobenzene (1817-77-2)

Conditions	Yield
With potassium phosphate tribasic trihydrate In toluene at 80℃; for 0.5h; Solvent; Temperature; Suzuki-Miyaura Coupling; Inert atmosphere;	99%
With sodium carbonate; trans-PdBr(N-Succ)(PPh3)2 In tetrahydrofuran at 80℃; for 3h; Suzuki-Miyaura cross-coupling;	93%
With cis,cis,cis-tetrakis[(diphenylphosphanyl)methyl]cyclopentane; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)) In xylene at 130℃; for 20h; Syzuki cross-coupling;	83%
With potassium carbonate; N,N-dimethyl-formamide; palladium dichloride In water at 90℃; for 1h; Suzuki Coupling;	77%
With water; sodium carbonate; triphenylphosphine; palladium dichloride In tetrahydrofuran at 40℃; for 24h; Suzuki-Miyaura Coupling; Sealed tube;	54 %Spectr.

L-Cysteine (52-90-4) + 4-nitrobenzyl chloride (100-14-1) → S-p-nitro-benzyl-L-cysteine (6341-94-2)

Conditions	Yield
With N,N,N',N'-tetramethylguanidine In tetrahydrofuran at 50℃; for 1h; Inert atmosphere;	99%

GLUTATHIONE (70-18-8) + 4-nitrobenzyl chloride (100-14-1) → S-(p-nitrobenzyl)-glutathione (6803-19-6)

Conditions	Yield
With N,N,N',N'-tetramethylguanidine In tetrahydrofuran at 50℃; for 1h; Inert atmosphere;	99%

4-nitrobenzyl chloride (100-14-1) + silver(I) trifluoromethanethiolate (811-68-7) → (4-nitrobenzyl)(trifluoromethyl)sulfane

Conditions	Yield
With potassium iodide In acetone at 20℃; for 1h;	99%

4-nitrobenzyl chloride (100-14-1) → 1-(azidomethyl)-2-nitrobenzene (95668-86-3)

Conditions	Yield
With sodium azide; ammonium chloride In water at 70℃; for 48h;	99%

5-acetyl-6-methyl-1-(prop-2-yn-1-yl)-4-[4-(prop-2-yn-1-yloxy)phenyl]-3,4-dihydropyrimidin-2(1H)-one + 4-nitrobenzyl chloride (100-14-1) → 5-acetyl-4-{4-[(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1-{[1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl]methyl}-6-methyl-3,4-dihydropyrimidin-2(1H)-one

Conditions	Yield
With copper(l) iodide; sodium azide; triethylamine at 100℃; for 0.0833333h; Microwave irradiation;	99%

4-nitrobenzyl chloride (100-14-1) → 4-nitrobenzaldehdye (555-16-8)

Conditions	Yield
With dipotassium hydrogenphosphate; dimethyl selenoxide; tetrabutylammomium bromide In 1,2-dimethoxyethane for 4h; Heating;	98%
With bismuth(III) nitrate; tetrabutyl ammonium fluoride at 100℃; for 2.7h;	95%
With 1-dodecyl-3-methylimidazolium iron chloride; periodic acid at 30℃; for 2.5h;	90%

para-xylene (106-42-3) + 4-nitrobenzyl chloride (100-14-1) → 1,4-dimethyl-2-(4-nitrobenzyl)benzene (85716-73-0)

Conditions	Yield
With graphite-supported iron oxide nanoparticles for 4h; Reflux;	98%
With iron(III) chloride for 6.5h; Heating;	83%

Boc-Lys(Fmoc)-OH (84624-27-1) + 4-nitrobenzyl chloride (100-14-1) → Boc-Lys(Fmoc) p-nitrobenzyl ester (134653-28-4)

Conditions	Yield
With sodium hydrogencarbonate; potassium iodide In N,N-dimethyl-formamide at 25℃; for 5h;	98%

phthalimide (136918-14-4) + 4-nitrobenzyl chloride (100-14-1) → 2-(4-nitrobenzyl)-1H-isoindole-1,3(2H)-dione (62133-07-7)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 8h; Alkylation;	98%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;	89%
With di-μ-hydroxo-bis[(N,N,N′,N′-tetramethylethylenediamine)copper(II)] chloride; caesium carbonate In acetonitrile at 20℃; for 4h;	85%

4-nitrobenzyl chloride (100-14-1) + 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isoselenuronium bromide (50793-60-7) → 4-nitrobenzyl 2,3,4,6-tetra-O-acetyl-1-seleno-β-D-glucopyranoside (1383478-47-4)

Conditions	Yield
With triethylamine In acetonitrile at 20℃;	98%

4-morpholinecarboxaldehyde (4394-85-8) + 4-nitrobenzyl chloride (100-14-1) → 4-(4-nitrobenzyl)morpholine (6425-46-3)

Conditions	Yield
With potassium hydroxide In water at 50℃; for 3h; Green chemistry;	98%
With NHC-Pd(II)-Im; sodium hydroxide In water at 50℃; for 3h; Inert atmosphere; Schlenk technique;	97%

N-Formylpiperidine (2591-86-8) + 4-nitrobenzyl chloride (100-14-1) → 1-(4-nitrobenzyl)piperidine (59507-44-7)

Conditions	Yield
With potassium hydroxide In water at 50℃; for 3h; Green chemistry;	98%

5-acetyl-6-methyl-4-phenyl-1-(prop-2-yn-1-yl)-3,4-dihydropyrimidin-2(1H)-one (1315320-86-5) + 4-nitrobenzyl chloride (100-14-1) → 5-acetyl-6-methyl-1-{[1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl]methyl}-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

Conditions	Yield
With copper(l) iodide; sodium azide; triethylamine at 100℃; for 0.05h; Microwave irradiation;	98%

4-nitrobenzyl chloride (100-14-1) → (p-nitrophenyl)methanethiol (26798-33-4)

Conditions	Yield
With hydrosulfide exchange resin In acetonitrile at 25℃; for 0.25h;	97%
With ammonium sulfide
(i) thiourea, (ii) aq. NaOH; Multistep reaction;

4-nitrobenzyl chloride (100-14-1) + Boc-Arg(NO2) → Boc-(NO2)Arg-PNB

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 80℃; for 12h;	97%

5-acetyl-6-methyl-4-(4-(prop-2-yn-1-yloxy)phenyl)-3,4-dihydropyrimidin-2(1H)-one + 4-nitrobenzyl chloride (100-14-1) → 5-acetyl-4-{4-[(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-6-methyl-3,4-dihydropyrimidin-2(1H)-one

Conditions	Yield
With copper(l) iodide; sodium azide; triethylamine at 100℃; for 0.05h; Microwave irradiation;	97%

5-(trifluoromethyl)-2(1H)-pyridone (33252-63-0) + 4-nitrobenzyl chloride (100-14-1) → 5-trifluoromethyl-(1-(4-nitro)benzyl)pyridine-2(1H)-one (923688-20-4)

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 130℃; for 4h;	96.9%

4-nitrobenzyl chloride (100-14-1) + aniline (62-53-3) → N,N-bis(4-nitrobenzyl)aniline (110392-56-8)

Conditions	Yield
With sodium dodecyl-sulfate; sodium hydrogencarbonate In water at 80℃; for 1.5h;	96%
With sodium carbonate

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• 1001397-43-8 4-BroMo-piperidine hydrochloride 
• 1001397-31-4 1-(5-Fluoro-pyrimidin-2-yl)-piperidin-4-ol 
• 100139-54-6 4-(DIETHYLAMINO)BENZHYDRAZIDE 
• 1001394-86-0 4-bromo-1-(pyridine-3-ylsulfonyl)-1H-indole 
• 1001394-83-7 4-bromo-1-(2-thienylsulfonyl)-1H-indole 
• 1001394-81-5 4-bromo-1-{[3-(trifluoromethyl)phenyl]sulfonyl}-1H-indole 
• 100139-31-9 2-Quinazolinepropionic acid, 3-amino-3,4-dihydro-8-methoxy-4-oxo-, hydrazide (6CI) 
• 100139-01-3 4(3H)-Quinazolinone, 3-amino-6,7,8-trimethoxy-2-methyl- 
• 100138-76-9 1-acetyl-4-{2-nitrophenyl}piperazine 
• 100138-46-3 4-BENZOYL-PIPERAZINE-1-CARBOXYLIC ACID AMIDE 

Downstream Products

• 70261-82-4 4-[(4-Methylpiperazin-1-yl)methyl]aniline 
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