2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide

Base Information

Chemical Name:2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide
CAS No.:61019-15-6
Molecular Formula:C₁₁H₉FN₂OS
Molecular Weight:236.27
Hs Code.:
DSSTox Substance ID:DTXSID20433412

Synonyms:2-amino-5-(2-fluorophenyl)thiophene-3-carboxamide;61019-15-6;3-thiophenecarboxamide,2-amino-5-(2-fluorophenyl)-;SCHEMBL3508176;DTXSID20433412;DWUVPXNRZKQAHM-UHFFFAOYSA-N

Suppliers and Price of 2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:236.04196225
Heavy Atom Count:16
Complexity:277

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=CC(=C(S2)N)C(=O)N)F

Technology Process of 2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide

There total 6 articles about 2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093878-00-2
benzyl [3-(aminocarbonyl)-5-(2-fluorophenyl)-2-thienyl]carbamate

: 61019-15-6
2-Amino-5-(2-fluoro-phenyl)-thiophene-3-carboxylic acid amide

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; at 80 ℃;
DOI:10.1016/j.bmcl.2014.02.064

Reference yield:

: 75321-85-6
2-(2-fluorophenyl)acetaldehyde

: 107-91-5
cyanoacetic acid amide

: 61019-15-6
2-Amino-5-(2-fluoro-phenyl)-thiophene-3-carboxylic acid amide

Guidance literature:: With morpholine; sulfur; In ethanol; at 70 ℃;
DOI:10.1016/j.bmcl.2014.02.064

Reference yield:

: 14080-51-4
2-aminothiophene-3-carboxamide

: 61019-15-6
2-Amino-5-(2-fluoro-phenyl)-thiophene-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

2: N-iodo-succinimide / dichloromethane

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 100 °C

4: palladium on activated charcoal; hydrogen / ethanol / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; palladium on activated charcoal; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 3: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.02.064