3-Methyl-2,6-diphenylpyridine

Base Information

• Chemical Name: 3-Methyl-2,6-diphenylpyridine
• CAS No.: 28489-52-3
• Molecular Formula: C18H15 N
• Molecular Weight: 245.324
• Hs Code.: 2933399090
• European Community (EC) Number: 249-054-9
• DSSTox Substance ID: DTXSID00182714
• Nikkaji Number: J250.726I
• Mol file: 28489-52-3.mol

Synonyms:3-Methyl-2,6-diphenylpyridine;28489-52-3;EINECS 249-054-9;3-Picoline, 2,6-diphenyl-;SCHEMBL10205828;DTXSID00182714;Pyridine, 3-methyl-2,6-diphenyl-

Chemical Property of 3-Methyl-2,6-diphenylpyridine

Chemical Property:

• Vapor Pressure: 1.78E-05mmHg at 25°C
• Boiling Point: 374.6°Cat760mmHg
• Flash Point: 161.8°C
• PSA: 12.89000
• Density: 1.068g/cm³
• LogP: 4.72400
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 245.120449483
• Heavy Atom Count: 19
• Complexity: 263

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=C(C=C1)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 3-Methyl-2,6-diphenylpyridine

There total 21 articles about 3-Methyl-2,6-diphenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-methylglutaronitrile (4553-62-2) + phenylboronic acid (98-80-6) → 2,6-diphenyl-3-methylpyridine (28489-52-3)

Guidance literature:

With [2,2]bipyridinyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2,2-trifluoroacetic acid ammonia; trifluoroacetic acid; In methanol; at 90 ℃; for 48h; Schlenk technique;

DOI:10.1021/acs.joc.9b02999

Reference yield: 77.0%

1-Phenyl-1-propanol (93-54-9) + 3-amino-3-phenyl-1-propanol (14593-04-5,82769-76-4) → 2,6-diphenyl-3-methylpyridine (28489-52-3)

Guidance literature:

With C₁₇H₁₁Cl₂N₃O₃Ru; potassium tert-butylate; In toluene; at 110 ℃; for 6h;

DOI:10.1021/acs.organomet.8b00359

Reference yield: 75.0%

2-carboxy-5-methylpyridine (4434-13-3) + bromobenzene (108-86-1,52753-63-6) → 2,6-diphenyl-3-methylpyridine (28489-52-3)

Guidance literature:

With copper(I) oxide; bis(benzonitrile)palladium(II) dichloride; potassium carbonate; triphenylphosphine; dimethyl sulfate; In N,N-dimethyl acetamide; at 150 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201400900

upstream raw materials:

4-methyl-1,5-diphenyl-penta-2,4-dien-1-one oxime

5-(2-Oxo-1-methyl-2-phenylethyl)-3-phenyl-2-isoxazoline

2-methyl-1-phenyl-3-butene-1-ol

1-Phenyl-2-(3-phenyl-4,5-dihydro-isoxazol-5-yl)-propan-1-ol