1-Phenyl-2-(3-phenyl-4,5-dihydro-isoxazol-5-yl)-propan-1-ol

Base Information

• Chemical Name: 1-Phenyl-2-(3-phenyl-4,5-dihydro-isoxazol-5-yl)-propan-1-ol
• CAS No.: 134370-19-7
• Molecular Formula: C₁₈H₁₉NO₂
• Molecular Weight: 281.354
• Mol file: 134370-19-7.mol

Synonyms:1-Phenyl-2-(3-phenyl-4,5-dihydro-isoxazol-5-yl)-propan-1-ol

Chemical Property of 1-Phenyl-2-(3-phenyl-4,5-dihydro-isoxazol-5-yl)-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Phenyl-2-(3-phenyl-4,5-dihydro-isoxazol-5-yl)-propan-1-ol

There total 1 articles about 1-Phenyl-2-(3-phenyl-4,5-dihydro-isoxazol-5-yl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-methyl-1-phenyl-3-butene-1-ol (25201-44-9) + benzohydroximoyl chloride (698-16-8) → 1-Phenyl-2-(3-phenyl-4,5-dihydro-isoxazol-5-yl)-propan-1-ol (134370-19-7)

Guidance literature:

With triethylamine; In diethyl ether; Ambient temperature;

DOI:10.1246/bcsj.64.375

Reference yield:

1-Phenyl-2-(3-phenyl-4,5-dihydro-isoxazol-5-yl)-propan-1-ol (134370-19-7) → 2,6-diphenyl-3-methylpyridine (28489-52-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) (COCl)2, DMSO, 3) Et₃N

2: 55 percent / H₂, 42percent aq. HBF₃ / Raney Ni / ethanol / 16 h / 760 Torr / Ambient temperature

With tetrafluoroboric acid; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; nickel; In ethanol;

DOI:10.1246/bcsj.64.375

Reference yield:

1-Phenyl-2-(3-phenyl-4,5-dihydro-isoxazol-5-yl)-propan-1-ol (134370-19-7) → 5-(2-Oxo-1-methyl-2-phenylethyl)-3-phenyl-2-isoxazoline (134370-17-5,134370-30-2)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; Yield given. Multistep reaction;

DOI:10.1246/bcsj.64.375

upstream raw materials:

2-methyl-1-phenyl-3-butene-1-ol

benzohydroximoyl chloride

Downstream raw materials:

5-(2-Oxo-1-methyl-2-phenylethyl)-3-phenyl-2-isoxazoline

2,6-diphenyl-3-methylpyridine