Butanamide, N-[(1S)-1-(1,3-dioxolan-2-yl)-3-phenylpropyl]-2-hydroxy-3-methyl-, (2S)-

Base Information

Chemical Name:Butanamide, N-[(1S)-1-(1,3-dioxolan-2-yl)-3-phenylpropyl]-2-hydroxy-3-methyl-, (2S)-
CAS No.:611210-35-6
Molecular Formula:C17H25NO4
Molecular Weight:307.39
Hs Code.:

Synonyms:

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Chemical Property of Butanamide, N-[(1S)-1-(1,3-dioxolan-2-yl)-3-phenylpropyl]-2-hydroxy-3-methyl-, (2S)-

Chemical Property:

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Technology Process of Butanamide, N-[(1S)-1-(1,3-dioxolan-2-yl)-3-phenylpropyl]-2-hydroxy-3-methyl-, (2S)-

There total 6 articles about Butanamide, N-[(1S)-1-(1,3-dioxolan-2-yl)-3-phenylpropyl]-2-hydroxy-3-methyl-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 611210-18-5
(1S)-1-(1,3-dioxolan-2-yl)-3-phenylpropan-1-amine

: 611210-35-6
(2S)-N-[(1S)-1-(1,3-dioxolan-2-yl)-3-phenylpropyl]-2-hydroxy-3-methylbutanamide

Guidance literature:: With 3-dimethylaminopropylcarbodiimide monohydrochloride; benzotriazol-1-ol; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2003.09.031

Reference yield:

: 27038-09-1
(2S)-2-amino-4-phenyl-1-butanol

: 611210-35-6
(2S)-N-[(1S)-1-(1,3-dioxolan-2-yl)-3-phenylpropyl]-2-hydroxy-3-methylbutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / Et₃N / tetrahydrofuran / 18 h / 20 °C

2: 94 percent / ethyldiisopropylamine; SO₃/pyridine / CH₂Cl₂; dimethylsulfoxide / 0.5 h / cooling

3: 24 percent / pyridinium tosylate / toluene / 18 h / 80 °C

4: 82 percent / H₂ / Pd/C / ethyl acetate / 18 h / 20 °C / atmospheric pressure

5: 84 percent / benzotriazol-1-ol; Et₃N; 1-[3-(dimethylamino)propyl]carbodiimide*HCl / dimethylformamide; CH₂Cl₂ / 18 h / 20 °C

With pyridine; 3-dimethylaminopropylcarbodiimide monohydrochloride; sulfur trioxide; hydrogen; pyridinium p-toluenesulfonate; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2003.09.031

Reference yield:

: 207305-48-4
N-(benzyloxycarbonyl)-homo-L-phenylalaninal

: 611210-35-6
(2S)-N-[(1S)-1-(1,3-dioxolan-2-yl)-3-phenylpropyl]-2-hydroxy-3-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 24 percent / pyridinium tosylate / toluene / 18 h / 80 °C

2: 82 percent / H₂ / Pd/C / ethyl acetate / 18 h / 20 °C / atmospheric pressure

3: 84 percent / benzotriazol-1-ol; Et₃N; 1-[3-(dimethylamino)propyl]carbodiimide*HCl / dimethylformamide; CH₂Cl₂ / 18 h / 20 °C

With 3-dimethylaminopropylcarbodiimide monohydrochloride; hydrogen; pyridinium p-toluenesulfonate; benzotriazol-1-ol; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2003.09.031