2-(4-Fluorophenyl)-5-methyl-1,3-oxazole-4-carboxylic acid

Base Information

Chemical Name:2-(4-Fluorophenyl)-5-methyl-1,3-oxazole-4-carboxylic acid
CAS No.:61152-03-2
Molecular Formula:C₁₁H₈FNO₃
Molecular Weight:221.188
Hs Code.:
DSSTox Substance ID:DTXSID30424437

Synonyms:61152-03-2;2-(4-fluorophenyl)-5-methyl-1,3-oxazole-4-carboxylic acid;4-Oxazolecarboxylic acid, 2-(4-fluorophenyl)-5-methyl-;2-(4-Fluorophenyl)-5-methyloxazole-4-carboxylic acid;SCHEMBL9832175;DTXSID30424437;AKOS011518040

Suppliers and Price of 2-(4-Fluorophenyl)-5-methyl-1,3-oxazole-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-(4-Fluorophenyl)-5-methyl-1,3-oxazole-4-carboxylic acid

Chemical Property:

PSA：63.33000
LogP:2.48730
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:221.04882128
Heavy Atom Count:16
Complexity:266

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(N=C(O1)C2=CC=C(C=C2)F)C(=O)O

Technology Process of 2-(4-Fluorophenyl)-5-methyl-1,3-oxazole-4-carboxylic acid

There total 3 articles about 2-(4-Fluorophenyl)-5-methyl-1,3-oxazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51655-76-6
ethyl 2-(4-fluorophenyl)-5-methyloxazole-4-carboxylate

: 61152-03-2
2-(4-fluoro-phenyl)-5-methyl-oxazole-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol;

Reference yield:

: 61151-94-8
2-(4-fluoro-benzoylamino)-3-oxo-butyric acid ethyl ester

: 61152-03-2
2-(4-fluoro-phenyl)-5-methyl-oxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃ / benzene / Heating

2: NaOH / ethanol

With sodium hydroxide; trichlorophosphate; In ethanol; benzene;

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 61152-03-2
2-(4-fluoro-phenyl)-5-methyl-oxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: (i) Zn, aq. H₂SO₄, (ii) /BRN= 386215/

2: POCl₃ / benzene / Heating

3: NaOH / ethanol

With sodium hydroxide; trichlorophosphate; In ethanol; benzene;