3-(2-NITRO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-(2-NITRO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER
• CAS No.: 61158-02-9
• Molecular Formula: C10H9NO5
• Molecular Weight: 223.18200
• Mol file: 61158-02-9.mol

Synonyms:Methyl-o-nitrobenzoylacetat;methyl 2-nitrobenzoylacetate;Methyl-o-methoxyhippurat;Methyl-o-N,N-dimethylaminomethylbenzoat;

Chemical Property of 3-(2-NITRO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER

Chemical Property:

• Melting Point: 41-42 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
• Boiling Point: 340.5±17.0 °C(Predicted)
• PKA: 9.40±0.46(Predicted)
• PSA: 89.19000
• Density: 1.318±0.06 g/cm3(Predicted)
• LogP: 1.86380

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-(2-nitrophenyl)-3-oxopropanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-NITRO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER

There total 2 articles about 3-(2-NITRO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ortho-nitrobenzoic acid (552-16-9,104810-18-6) + monomethyl monopotassium malonate (38330-80-2) → methyl 3-(2-nitrophenyl)-3-oxopropanoate (61158-02-9)

Guidance literature:

ortho-nitrobenzoic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; at 20 ℃; for 1h;

monomethyl monopotassium malonate; With magnesium chloride; In acetonitrile; for 90h;

DOI:10.1021/acs.joc.5b02467

Reference yield:

→ methyl 3-(2-nitrophenyl)-3-oxopropanoate (61158-02-9)

Guidance literature:

Methyl-o-nitrobenzoylacetoacetat (Kalium-Verb.) in Wasser, Zugabe von NH4Cl bei 80-90grad;

Reference yield: 86.0%

methyl 3-(2-nitrophenyl)-3-oxopropanoate (61158-02-9) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 3-(2-nitrobenzoyl)-4-phenylquinolin-2-ol (107263-26-3)

Guidance literature:

With acetic acid; at 160 ℃; for 1h;

upstream raw materials:

ortho-nitrobenzoic acid

monomethyl monopotassium malonate

Downstream raw materials:

N-(5-Methoxy-2,3-dihydro-benzofuran-6-yl)-3-(2-nitro-phenyl)-3-oxo-propionamide

3-(2-nitrobenzoyl)-4-phenylquinolin-2-ol

2-Chloro-6-(2-hydroxy-ethyl)-4-(2-nitro-phenyl)-quinoline-5,8-dione

7-Chloro-5-methoxy-9-(2-nitro-phenyl)-2,3-dihydro-furo[2,3-f]quinoline

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 61158-02-9 3-(2-NITRO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send