2-Aminobenzophenone

Base Information

• Chemical Name: 2-Aminobenzophenone
• CAS No.: 2835-77-0
• Molecular Formula: C13H11NO
• Molecular Weight: 197.236
• Hs Code.: 29223900
• European Community (EC) Number: 220-613-9
• NSC Number: 9422
• UNII: SY4HY89TQ9
• DSSTox Substance ID: DTXSID00182592
• Nikkaji Number: J95.043B
• Wikidata: Q63148545
• ChEMBL ID: CHEMBL1241132
• Mol file: 2835-77-0.mol

Synonyms:2-Aminobenzophenone;2835-77-0;2-Benzoylaniline;o-Benzoylaniline;o-Aminobenzophenone;(2-aminophenyl)(phenyl)methanone;Benzophenone, 2-amino-;(2-aminophenyl)-phenylmethanone;Methanone, (2-aminophenyl)phenyl-;2-Aminophenyl phenyl ketone;(2-Amino-phenyl)-phenyl-methanone;Methanone, (aminophenyl)phenyl-;2-amino-benzophenone;NSC 9422;MFCD00007713;2-Aminobenzophenone, 98%;NSC-9422;EINECS 220-613-9;AI3-22137;aminobenzophenone;2-aminobenzophenon;o-amino benzophenone;2-Benzoylbenzenamine;2-aminobenzo-phenone;2-(Phenylcarbonyl)aniline;o-Aminophenyl phenyl ketone;SY4HY89TQ9;Oprea1_344183;Oprea1_386897;SCHEMBL28746;MLS000103987;(2-Aminophenyl)phenylmethanone;F0257-0055;IFLab1_000932;CHEMBL1241132;MAOBFOXLCJIFLV-UHFFFAOYSA-;(2-aminophenyl)-phenyl-methanone;DTXSID00182592;NSC9422;HMS1414K08;HMS2258M05;STR01813;STK092629;AKOS000269011;CCG-104466;CS-M-57696;CS-W010565;PS-5228;AC-24976;BP-10759;SMR000015734;SY010724;A0788;AM20060591;FT-0611232;EN300-18137;SR-01000403842;SR-01000403842-1;W-107052;Q63148545;Z57201606

Chemical Property of 2-Aminobenzophenone

Chemical Property:

• Appearance/Colour: yellow-gold fine crystalline powder
• Vapor Pressure: 4.31E-06mmHg at 25°C
• Melting Point: 103-107 °C(lit.)
• Refractive Index: 1.628
• Boiling Point: 383.7 °C at 760 mmHg
• PKA: 0.33±0.10(Predicted)
• Flash Point: 185.9 °C
• PSA: 43.09000
• Density: 1.161 g/cm³
• LogP: 3.08100
• Storage Temp.: Store below +30°C.
• Solubility.: DMSO, Methanol
• Water Solubility.: practically insoluble
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 197.084063974
• Heavy Atom Count: 15
• Complexity: 221

Purity/Quality:

99% ^*data from raw suppliers

2-Aminobenzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=CC=CC=C2N
• Uses: 2-Aminobenzophenone is a derivative of Benzophenone (B204980), used in the manufacturing of antihistamines, hypnotics, insecticides. 2-Aminobenzophenone was shown to exhibit modulation activity of GAB AA receptor-mediated currents in isolated purkinje neurons. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuffs.

Technology Process of 2-Aminobenzophenone

There total 150 articles about 2-Aminobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2-aminophenyl)(phenyl)methanol (13209-38-6) → (2-aminophenyl)(phenyl)methanone (2835-77-0)

Guidance literature:

With bismuth (III) nitrate pentahydrate; cellulose supported copper⁽⁰⁾; oxygen; In acetonitrile; at 60 ℃; for 0.5h;

DOI:10.1016/j.catcom.2016.01.003

Reference yield: 95.0%

2-nitrobenzophenone (2243-79-0) → (2-aminophenyl)(phenyl)methanone (2835-77-0)

Guidance literature:

With sodium tetrahydroborate; In water; at 40 ℃; for 2h; chemoselective reaction;

DOI:10.1002/aoc.3975

Reference yield: 95.0%

(2-nitrophenyl)phenylmethanol (5176-12-5) → (2-aminophenyl)(phenyl)methanone (2835-77-0)

Guidance literature:

With palladium on activated charcoal; hydrogen; acetic acid; In methanol; at 20 ℃; for 5h; under 760.051 Torr;

DOI:10.1039/c6ob00423g

upstream raw materials:

formic acid

syn-2-aminobenzophenone oxime

(Z)-(2-aminophenyl)(phenyl)methanone oxime

isatoic anhydride

Downstream raw materials:

1-(2-benzoylphenyl)-3-phenylthiourea

N-(2-benzoylphenyl)propionamide

2-{Phenyl-[(E)-phenylimino]-methyl}-phenylamine

10-phenyl-benzo-1,5-naphthyridine

Refernces

• 1、 Acharya, Baman Prasad,Misra, Bijaya Kumar,Rao, Yerramalli Ramachandra. "Mass Spectral and Pyrolitic Studies of Some 4,4-Disubstituted 1,4-Dihydro-2H-3,1-benzoxazin-2-ones". . p. 4417 - 4420. Retrieved 1987.
• 2、 Fan, Hui,Xu, Shijie,Yang, Fan,Zhang, Xiaoxiang,Zhao, Xuechun. "One-Pot Synthesis of 2-Aminobenzophenones from 2-Alkynyl Arylazides Catalyzed by Pd and Cu Precursors". supporting information. p. 4555 - 4558. Retrieved 2021/08/30.
• 3、 Li, Quanzhe,Liu, Jiaxin,Wei, Yin,Shi, Min. "One-Pot Synthesis of Spirocyclopenta[ a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization". supporting information. p. 2438 - 2455. Retrieved 2020/01/31.