2'-Methoxyacetophenonesemicarbazone

Base Information

• Chemical Name: 2'-Methoxyacetophenonesemicarbazone
• CAS No.: 22233-80-3
• Molecular Formula: C10H13 N3 O2
• Molecular Weight: 207.232
• NSC Number: 106251
• DSSTox Substance ID: DTXSID80418947
• Nikkaji Number: J1.591.557I
• Mol file: 22233-80-3.mol

Synonyms:NSC106251;22233-80-3;DTXSID80418947;2'-Methoxyacetophenonesemicarbazone;NSC-106251

Chemical Property of 2'-Methoxyacetophenonesemicarbazone

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.19g/cm³
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 207.100776666
• Heavy Atom Count: 15
• Complexity: 253

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=NNC(=O)N)C1=CC=CC=C1OC
• Isomeric SMILES: C/C(=N/NC(=O)N)/C1=CC=CC=C1OC

Technology Process of 2'-Methoxyacetophenonesemicarbazone

There total 6 articles about 2'-Methoxyacetophenonesemicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methoxyacetophenone (579-74-8) + semicarbazide hydrochloride (563-41-7) → 1-(2-methoxy-phenyl)-ethanone semicarbazone (22233-80-3)

Guidance literature:

semicarbazide hydrochloride; With sodium acetate; In ethanol; for 0.75h; Heating;

2-Methoxyacetophenone; In ethanol; for 1h; Heating;

DOI:10.1007/s11176-005-0318-7

Reference yield:

1-(2-methoxyphenyl)ethanol (13513-82-1) → 1-(2-methoxy-phenyl)-ethanone semicarbazone (22233-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium dichromate; sulfuric acid

2: alcohol

With potassium dichromate; ethanol; sulfuric acid;

Reference yield:

2-methoxy-benzonitrile (6609-56-9) → 1-(2-methoxy-phenyl)-ethanone semicarbazone (22233-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / und Erhitzen des vom Aether befreiten Reaktiongemisches mit wss.Essigsaeure

With diethyl ether;

upstream raw materials:

2-Methoxyacetophenone

hydrazine carboxamide

semicarbazide hydrochloride

1-(2-methoxyphenyl)ethanol

Downstream raw materials:

2-Methoxyacetophenone

3-(2-methoxy-phenyl)-1⁽²⁾H-pyrazole-4-carbaldehyde

3-(2-methoxy-phenyl)-1H-pyrazole-4-carboxylic acid