3,4'-Dihydroxybenzophenone

Base Information

• Chemical Name: 3,4'-Dihydroxybenzophenone
• CAS No.: 611-81-4
• Molecular Formula: C13H10O3
• Molecular Weight: 214.221
• DSSTox Substance ID: DTXSID00454680
• Nikkaji Number: J134.639C
• Mol file: 611-81-4.mol

Synonyms:3,4'-dihydroxybenzophenone;3-(4-hydroxybenzoyl)phenol;611-81-4;(3-hydroxyphenyl)-(4-hydroxyphenyl)methanone;(3-hydroxyphenyl)(4-hydroxyphenyl)methanone;starbld0038822;3,4'-di-hydroxybenzophenone;SCHEMBL189236;DTXSID00454680;LJQVLJXQHTULEP-UHFFFAOYSA-N;MFCD19302479;AKOS022506274;NS-02442

Chemical Property of 3,4'-Dihydroxybenzophenone

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 214.062994177
• Heavy Atom Count: 16
• Complexity: 244

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)O)C(=O)C2=CC=C(C=C2)O

Technology Process of 3,4'-Dihydroxybenzophenone

There total 15 articles about 3,4'-Dihydroxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4,3'-dimethoxybenzophenone (75731-44-1) → (3-hydroxyphenyl)(4-hydroxyphenyl)methanone (611-81-4)

Guidance literature:

With pyridine hydrochloride; for 0.5h; Heating;

DOI:10.1016/S0040-4020(99)01061-3

Reference yield: 88.0%

3-hydroxy phenylacetylene (10401-11-3) + phenol (108-95-2,27073-41-2) → (3-hydroxyphenyl)(4-hydroxyphenyl)methanone (611-81-4)

Guidance literature:

With oxygen; copper(l) chloride; In acetonitrile; at 25 - 28 ℃; for 10h; regioselective reaction; Irradiation;

DOI:10.1021/jacs.6b13113

Reference yield: 87.9%

3-Carboxyphenol (99-06-9) + phenol (108-95-2,27073-41-2) → (3-hydroxyphenyl)(4-hydroxyphenyl)methanone (611-81-4)

Guidance literature:

3-Carboxyphenol; phenol; With hydrogen fluoride; boron trifluoride; at 20 - 30 ℃; Pressure reactor;

With ammonia; water; pH=4.5 - 6; Product distribution / selectivity; Cooling with ice;

upstream raw materials:

4,3'-dimethoxybenzophenone

3-methoxybenzoic acid phenyl ester

4-methoxy-2-(4-methoxy-benzoyl)-benzoic acid

3,4'-diamino benzophenone

Downstream raw materials:

3-hydroxy-4'-(methoxymethoxy)benzophenone

(4-methoxymethoxy-phenyl)-(3-methoxymethoxy-phenyl)-methanone

2-ferrocenyl-1-(3-hydroxyphenyl)-1-(4-hydroxyphenyl)-but-1-ene

3,4'-bis(4-aminophenoxy)-benzophenone