1-(4-Methyl-benzyl)-piperazine hydrochloride

Base Information

Chemical Name:1-(4-Methyl-benzyl)-piperazine hydrochloride
CAS No.:435345-17-8
Molecular Formula:C12H20N2+2
Molecular Weight:226.749
Hs Code.:
Mol file:435345-17-8.mol

Synonyms:1-(4-Methyl-benzyl)-piperazine hydrochloride;435345-17-8;1-(4-Methyl-benzyl)-piperazinehydrochloride;SCHEMBL2924133;AKOS015844768;1-[(4-methylphenyl)methyl]piperazine;hydrochloride

Suppliers and Price of 1-(4-Methyl-benzyl)-piperazine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(4-Methyl-benzyl)-piperazinehydrochloride
50mg
$ 110.00

Sigma-Aldrich
1-(4-Methylbenzyl)piperazine 97%
1 g
$ 35.50

Sigma-Aldrich
1-(4-Methylbenzyl)piperazine 97%
5 g
$ 146.00

Matrix Scientific
1-(4-Methyl-benzyl)-piperazinehydrochloride
500mg
$ 168.00

Total 4 raw suppliers

Chemical Property of 1-(4-Methyl-benzyl)-piperazine hydrochloride

Chemical Property:

Vapor Pressure:0.00192mmHg at 25°C
Melting Point:37-41oC(lit.)
Boiling Point:291.6°Cat760mmHg
Flash Point:120.3°C
PSA：15.27000
Density:g/cm³
LogP:1.66690
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:226.1236763
Heavy Atom Count:15
Complexity:156

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-Methyl-benzyl)-piperazinehydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 37/38-41
Safety Statements: 26-39

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)CN2CCNCC2.Cl
Uses 1-(4-Methylbenzyl)piperazine is a useful synthetic intermediate in the synthesis of 3-Desmethyl 4-Methyl Meclizine Dihydrochloride (D291930); a metabolite of Meclizine (M202700, 2HCl monohydrate) which is an antiemetic. 1-(4-Methylbenzyl)piperazine is also used in the synthesis of inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).

Technology Process of 1-(4-Methyl-benzyl)-piperazine hydrochloride

There total 3 articles about 1-(4-Methyl-benzyl)-piperazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 142-64-3,8006-71-1
piperazine dihydrochloride

: 104-82-5
4-Methylbenzyl chloride

: 435345-17-8
1-(4-methylbenzyl)piperazine hydrochloride

Guidance literature:: piperazine dihydrochloride; In methanol; Heating;

4-Methylbenzyl chloride; With copper(II) ions supported on commercial polymeric resin; Microwave irradiation; Reflux;
DOI:10.3390/molecules25092168

Reference yield: 71.0%

: 111752-26-2
piperazin-1-yl(p-tolyl)methanone

: 435345-17-8
1-(4-methylbenzyl)piperazine hydrochloride

Guidance literature:: piperazin-1-yl(p-tolyl)methanone; With bis(cyclopentadienyl)dihydrozirconium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; at 20 ℃; for 12h; under 760.051 Torr; Inert atmosphere;

With hydrogenchloride; In diethyl ether; Inert atmosphere;