Piperazine hydrochloride

Base Information

• Chemical Name: Piperazine hydrochloride
• CAS No.: 142-64-3
• Deprecated CAS: 8006-71-1
• Molecular Formula: C4H10N2·2ClH
• Molecular Weight: 159.059
• Hs Code.: 2933599550
• European Community (EC) Number: 228-042-7
• UNII: 7N36JHA4P6
• DSSTox Substance ID: DTXSID2064739
• Wikidata: Q27268592
• Mol file: 142-64-3.mol

Synonyms:1,4 Diazacyclohexane;1,4 Piperazine;1,4-Diazacyclohexane;1,4-piperazine;piperazine;piperazine diacetate;piperazine dihydrochloride;piperazine hexahydrate;piperazine hydrate;piperazine hydrobromide;piperazine hydrochloride;piperazine monohydrochloride;piperazine phosphate;piperazine phosphate (1:1);Piperazine Phosphate Anhydrous;piperazine salt;piperazine sulfate;Piperazine Tartrate;piperazine tartrate (1:1), (R-(R*,R*))-isomer;piperazine tartrate, (R-(R*,R*))-isomer;piperazinium oleate;Pripsen

Chemical Property of Piperazine hydrochloride

Chemical Property:

• Appearance/Colour: White to cream-colored needles or powder
• Melting Point: 248-250
• Refractive Index: 1.6300 (estimate)
• Boiling Point: 149.3 °C at 760 mmHg
• Flash Point: 49.7 °C
• PSA: 24.06000
• Density: 1.92g/cm3
• LogP: 1.44080
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Water
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 122.0610761
• Heavy Atom Count: 7
• Complexity: 26.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

Piperazine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-42/43
• Safety Statements: 22-26-36/37

MSDS Files:

Useful:

• Canonical SMILES: C1CNCCN1.Cl
• Uses: It is used as a one day wormer, either in water or feed, for the control of Round worms in poultry, swine, and horses. It also controls nodular worms in swine, and small strongyles in horses. In the manufacture of fibers, pharmarceuticals, and insecticides. Piperazine Dihydrochloride is an anthelmintic agent used in the treatment of parasitic worms in animals.

Technology Process of Piperazine hydrochloride

There total 45 articles about Piperazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

triphenylphosphine (603-35-0) + nickel dichloride (83864-14-6) → bis(triphenylphosphine)nickel(II) chloride (14264-16-5,53996-95-5,62075-39-2,39716-73-9)

Guidance literature:

In ethanol; heating with reflux;

Reference yield: 97.7%

[((C6H5)3P)3NiCl]2 → bis(triphenylphosphine)nickel(II) chloride (14264-16-5,53996-95-5,62075-39-2,39716-73-9) + nickel (7440-02-0) + nickel dichloride (83864-14-6)

Guidance literature:

In neat (no solvent); byproducts: triphenylphosphine; Ar-atmosphere; 140-180°C, 1 h; extn. (ether, CH2Cl2, H2O), evapn. of extract;

DOI:10.1016/S0020-1693(00)90496-1

Reference yield: 91.0%

nickel(II) chloride hexahydrate + triphenylphosphine (603-35-0) → bis(triphenylphosphine)nickel(II) chloride (14264-16-5,53996-95-5,62075-39-2,39716-73-9)

Guidance literature:

In ethanol; at 80 ℃; for 1h; Sealed tube; Inert atmosphere;

DOI:10.1021/om500156q

upstream raw materials:

piperazine

phosgene

toluene

benzene

Downstream raw materials:

Piperazin-diguanidin

piperazine

2-(4-ethylpiperazin-1-yl)ethan-1-ol

1,4-dinitropiperazine

Refernces

• 1、 Amasiatu, Ifeanyi S.,Egbujor, Melford C.,Egu, Samuel A.,Egwuatu, Pius I.,Eze, Florence U.,Okoro, Uchechukwu C.. "Synthesis and biological evaluation of alanine derived bioactive P-toluenesulphonamide analogs". . p. 6449 - 6458. Retrieved 2020/10/27.
• 2、 -. "Synthesis method of cinnamyl piperazine". Paragraph 0016; ; 0017; 0018; 0019. . Retrieved 2017/08/27.