L-Tyrosine, O-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: L-Tyrosine, O-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester
• CAS No.: 61342-80-1
• Molecular Formula: C17H27NO3
• Molecular Weight: 293.406
• Mol file: 61342-80-1.mol

Synonyms:t-butyl 3-(4-t-butyloxyphenyl)-2-aminopropionate;O-(tert-butyl) tert-butyl L tyrosinate;(S)-tert-butyl 2-amino-3-(4-tert-butoxyphenyl)propanoate;H-Tyr(tBu)-OtBu;Tyr(tBu)-OtBu;tert-butyl (S)-O4-tert-butyltyrosinate;

Chemical Property of L-Tyrosine, O-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 61.55000
• LogP: 3.77570

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Tyrosine, O-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester

There total 6 articles about L-Tyrosine, O-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-(9-fluorenylmethoxycarbonyl)(O-tert-butyl)tyrosine tert-butyl ester (129460-19-1) → tert-butyl (S)-3-(4-(tert-butoxy)phenyl)-2-aminopropanoate (61342-80-1)

Guidance literature:

With triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate; In neat (no solvent); at 25 ℃; Green chemistry;

DOI:10.1039/c7ra04425a

Reference yield: 57.0%

acetic acid tert-butyl ester (540-88-5) + L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → Tyr(tBu) (16874-12-7,87553-74-0) + tert-butyl (S)-3-(4-(tert-butoxy)phenyl)-2-aminopropanoate (61342-80-1)

Guidance literature:

With perchloric acid; at 14 ℃; for 18h;

DOI:10.1021/jm901133z

Reference yield: 43.0%

ammonium L-tyrosine tert-butylether tert-butyl ester chloride → tert-butyl (S)-3-(4-(tert-butoxy)phenyl)-2-aminopropanoate (61342-80-1)

Guidance literature:

With ruthenium nanoparticles dispersed in a polyvinylpyrrolidone matrix; amberlyst A-21; In methanol; dichloromethane;

DOI:10.1002/anie.201504554

upstream raw materials:

N-(9-fluorenylmethoxycarbonyl)(O-tert-butyl)tyrosine tert-butyl ester

Fmoc-Tyr(tBu)-OH

acetic acid tert-butyl ester

L-tyrosine

Downstream raw materials:

2-(4-acryloylamino-butyrylamino)-3-(4-tert-butoxy-phenyl)-propionic acid tert-butyl ester

C₄₁H₅₈N₂O₈Si

tert-butyl 2-(2-(5-benzyl-6-oxo-3-phenylpyridazin-1(6H)-yl)acetamido)-3-(4-tert-butoxyphenyl)propanoate

tert-butyl 2-(2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetamido)-3-(4-tert-butoxyphenyl)propanoate