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Tyrosine

Base Information Edit
  • Chemical Name:Tyrosine
  • CAS No.:60-18-4
  • Deprecated CAS:140-43-2,1991-85-1,46209-14-7,55520-40-6,1207451-88-4,2416148-26-8,1207451-88-4,46209-14-7,55520-40-6
  • Molecular Formula:C9H11NO3
  • Molecular Weight:181.191
  • Hs Code.:H11NO3 MOL WT. 181.19
  • European Community (EC) Number:200-460-4
  • UNII:42HK56048U
  • DSSTox Substance ID:DTXSID1023730
  • Nikkaji Number:J9.173A
  • Wikipedia:Tyrosine
  • Wikidata:Q188017,Q27115106
  • NCI Thesaurus Code:C915
  • RXCUI:10962
  • Metabolomics Workbench ID:37107
  • ChEMBL ID:CHEMBL925
  • Mol file:60-18-4.mol
Tyrosine

Synonyms:L Tyrosine;L-Tyrosine;para Tyrosine;para-Tyrosine;Tyrosine;Tyrosine, L isomer;Tyrosine, L-isomer

Suppliers and Price of Tyrosine
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Tyrosine
  • 200ul
  • $ 505.00
  • Usbiological
  • Tyr
  • 48Tests
  • $ 588.00
  • Usbiological
  • TYR
  • 48Tests
  • $ 588.00
  • Usbiological
  • Tyrosine
  • 200ul
  • $ 443.00
  • TRC
  • L-Tyrosine
  • 100mg
  • $ 55.00
  • TCI Chemical
  • L-(-)-Tyrosine >98.5%(T)
  • 100g
  • $ 73.00
  • TCI Chemical
  • L-(-)-Tyrosine >98.5%(T)
  • 25g
  • $ 28.00
  • TCI Chemical
  • L-(-)-Tyrosine >98.5%(T)
  • 500g
  • $ 310.00
  • SynQuest Laboratories
  • L-Tyrosine 99.5%
  • 1 kg
  • $ 136.00
  • SynQuest Laboratories
  • L-Tyrosine 99.5%
  • 100 g
  • $ 23.00
Total 393 raw suppliers
Chemical Property of Tyrosine Edit
Chemical Property:
  • Appearance/Colour:White to off-white powder 
  • Melting Point:>300 °C (dec.)(lit.) 
  • Refractive Index:-12 ° (C=5, 1mol/L HCl) 
  • Boiling Point:385.163 °C at 760 mmHg 
  • PKA:2.2(at 25℃) 
  • Flash Point:186.74 °C 
  • PSA:83.55000 
  • Density:1.334 g/cm3 
  • LogP:1.04690 
  • Storage Temp.:Store at RT. 
  • Solubility.:1 M HCl: 25 mg/mL 
  • Water Solubility.:0.45 g/L (25 ºC) 
  • XLogP3:-2.3
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:3
  • Exact Mass:181.07389321
  • Heavy Atom Count:13
  • Complexity:176
Purity/Quality:

98% *data from raw suppliers

Tyrosine *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Statements: 36/37/38-40 
  • Safety Statements: 26-36-37/39-22 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Chemical Classes:Biological Agents -> Amino Acids and Derivatives
  • Canonical SMILES:C1=CC(=CC=C1CC(C(=O)O)N)O
  • Isomeric SMILES:C1=CC(=CC=C1C[C@@H](C(=O)O)N)O
  • Recent ClinicalTrials:Contribution of L-Tyrosine to Human Decision Making in Stressful Situations
  • Recent NIPH Clinical Trials:Effect of immunotherapy on oncological and patientst reported outcomes in patients with metastatic renal cell cancer
  • Uses For biochemical research,it is used as amino acids nutritional in medicine for the treatment of polio, encephalitis, hyperthyroidism and other diseases. Nutritional supplements. for the manufacture of L-dopa diiodo tyrosine. After aminocarbonyl hot reaction with sugars, it can generate a special flavor substances. For tissue culture (L-tyrosine· 2Na· H2O), biochemical reagents, treatment of hyperthyroidism. Also available as modulation for rhe eldee, children's food and nutrition agents of plant leaves. tyrosine is an amino acid. Cutaneous applications may produce an extra reserve of tyrosine in the skin, assisting or “activating” melanin synthesis. This in turn should increase and prolong the effect of the tanning process. Tyrosine’s effect is improved if the product contains vitamin B (riboflavin) plus an additional compound referred to chemically as ATP (adenosine triphosphate). experiments conducted with l-tyrosine in the form of watersoluble derivatives found that it penetrates the epidermis to the basal layer where the melanocytes are located. It is used in suntan accelerators and in skin-bronzing cosmetics to accelerate the tanning process. L-Tyrosine is one of the 22 proteinogenic amino acids that are used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.
  • Production Method after precipitation of the casein, silk and other protein acid hydrolyzates,dissolve in dilute aqueous ammonia, with acetic acid neutralize to pH = 5, recrystallization to derive it. Extract The pig hydrolyzate to get second crude liquid crystalline pure cystine, store two days at 20 ℃, tyrosine precipitation, filtration, available tyrosine crude, refine also to receive L-Tyrosine . 1% Of pig yield. Casein as raw materials, reflux for several in hourshydrochloric acid , filter, and concentrate, soda and charcoal, crystallize,obtain products. Production of L-Tyrosine mainly takes proteolysis extraction. blood meal, hoof angle, silk and other raw materials, acid hydrolysis, separation and purification. Blood meal [HCl (hydrolysis)] → [110 ℃, 24h] hydrolyzate [rush acid] → [concentrated by evaporation] In addition to the acid [charcoal] → destaining solution [bleaching, cooling and crystallization] → L-Tyrosine crude [Activated Carbon (refined)] → [90 ℃, 30min] filtrate [crystalline] → L-tyrosine. Hydrolysis, rush acid the blood meal, water, industrial hydrochloric as 1: 1.3: 1 ratio by weight, respectively put into the hydrolyzed cylinder, heat to 112-114 ℃, stop after 24h of stirring under reflux , cool and filter to remove, give filtrate which is hydrolyzate . The hydrolyzate is concentrated by evaporation to a syrup, add water to dissolve ,oncentrated by evaporation, so repeat three times to rush the acid. Bleaching, crystallized concentrate is diluted with distilled water to the whole solution,add aqueous ammonia solution to pH 3.5, 1% charcoal is added, boiling with stirring 10min, stirring in a water bath at 90 ℃ incubated 30min, filter while hot, active carbon layer is washed with distilled water 3 times, and the filtrate and washings are combined. According to the Act, continue to use active carbon to make the solution pale yellow. The filtrate is placed in quiet place below 10 ℃ 24h, ie, crystalline precipitation, filtration to obtain crude L-tyrosine. Recrystallized tyrosine crude 1:20 distilled water is added, after the whole solution, plus 1% activated carbon, 90 ℃ insulation mixing 30min, filter hot and the filtrate cool to refined crystallize . The crystals are collected by filtration, washed with anhydrous ethanol twice, 60 ℃ drying, the finished product is L-tyrosine.
Technology Process of Tyrosine

There total 323 articles about Tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
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