5-Methoxy-2-(prop-2-en-1-yl)benzoic acid

Base Information

Chemical Name:5-Methoxy-2-(prop-2-en-1-yl)benzoic acid
CAS No.:61436-79-1
Molecular Formula:C11H12O3
Molecular Weight:192.214
Hs Code.:
DSSTox Substance ID:DTXSID30493148
Wikidata:Q82339637

Synonyms:61436-79-1;5-Methoxy-2-(prop-2-en-1-yl)benzoic acid;SCHEMBL20803393;DTXSID30493148

Suppliers and Price of 5-Methoxy-2-(prop-2-en-1-yl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Methoxy-2-(prop-2-en-1-yl)benzoic acid

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:192.078644241
Heavy Atom Count:14
Complexity:213

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)CC=C)C(=O)O

Technology Process of 5-Methoxy-2-(prop-2-en-1-yl)benzoic acid

There total 8 articles about 5-Methoxy-2-(prop-2-en-1-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 560134-48-7
methyl 5-methoxy-2-(prop-2-enyl)benzoate

: 61436-79-1
5-methoxy-2-(prop-2-enyl)benzoic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; for 1h; Heating;
DOI:10.1021/jo0268512

Reference yield:

: 57772-57-3
5-hydroxy-2-iodo-benzoic acid

: 61436-79-1
5-methoxy-2-(prop-2-enyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 24 h / Inert atmosphere; Reflux

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere

2.2: 0.17 h / -40 - -30 °C / Inert atmosphere

2.3: 20 °C / Inert atmosphere

3.1: water; sodium hydroxide / methanol / 6 h / Inert atmosphere

With water; isopropylmagnesium chloride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; acetone;
DOI:10.1002/chem.201403561

Reference yield:

: 35450-36-3
methyl 2-bromo-5-methoxybenzoate

: 61436-79-1
5-methoxy-2-(prop-2-enyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / Pd(PPh₃)4 / benzene / 20 h / 120 °C

2: 79 percent / NaOH / H₂O; ethanol / 1 h / Heating

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; benzene;
DOI:10.1021/jo0268512