N-Ethyl-4-hydroxypiperidine

Base Information

• Chemical Name: N-Ethyl-4-hydroxypiperidine
• CAS No.: 3518-83-0
• Molecular Formula: C7H15NO
• Molecular Weight: 129.202
• Hs Code.: 2933399090
• European Community (EC) Number: 222-528-2
• UNII: M2F8HJ4QKP
• DSSTox Substance ID: DTXSID00188670
• Nikkaji Number: J216.169I
• Wikidata: Q72475357
• ChEMBL ID: CHEMBL4526324
• Mol file: 3518-83-0.mol

Synonyms:N-Ethyl-4-hydroxypiperidine;3518-83-0;1-Ethylpiperidin-4-ol;1-Ethyl-4-hydroxypiperidine;4-Piperidinol, 1-ethyl-;1-Ethyl-4-piperidinol;EINECS 222-528-2;M2F8HJ4QKP;MFCD00006509;N-ethyl-4-hydroxy piperidine;1-ethyl-piperidin-4-ol;UNII-M2F8HJ4QKP;1-Ethyl-4-piperidinol #;4-hydroxy-N-ethylpiperidine;4-hydroxy-1-ethylpiperidine;SCHEMBL69424;CHEMBL4526324;DTXSID00188670;CS-M1296;STL387995;AKOS000249636;MB00190;AS-17355;SY033662;AM20090554;FT-0634887;EN300-45452;A822634;J-019982;J-523562;Z197264618

Chemical Property of N-Ethyl-4-hydroxypiperidine

Chemical Property:

• Vapor Pressure: 0.0468mmHg at 25°C
• Refractive Index: 1.4800 (589.3 nm 20℃)
• Boiling Point: 209.3 °C at 760 mmHg
• PKA: 14.88±0.20(Predicted)
• Flash Point: 95.6 °C
• PSA: 23.47000
• Density: 0.978 g/cm³
• LogP: 0.40090
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 129.115364102
• Heavy Atom Count: 9
• Complexity: 77

Purity/Quality:

97% ^*data from raw suppliers

N-Ethyl-4-hydroxypiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1CCC(CC1)O

Technology Process of N-Ethyl-4-hydroxypiperidine

There total 8 articles about N-Ethyl-4-hydroxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-HYDROXYPIPERIDINE (5382-16-1) + acetonitrile (75-05-8,26809-02-9) → 1-ethylpiperidin-4-ol (3518-83-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 66h; under 760.051 Torr;

DOI:10.1039/c1ob06303k

Reference yield:

N-ethyl-4-piperidone (3612-18-8) → 1-ethylpiperidin-4-ol (3518-83-0)

Guidance literature:

With water; nickel; under 2942.03 Torr; Hydrogenation_.bei pH 6.5-7.0;

Reference yield:

→ 1-ethylpiperidin-4-ol (3518-83-0)

Guidance literature:

With platinum(IV) oxide; ethanol; under 1520 - 2280 Torr; Hydrogenation;

upstream raw materials:

pyridin-4-ol

N-ethyl-4-piperidone

N-acetyl-4-hydroxypiperidine

4-HYDROXYPIPERIDINE

Downstream raw materials:

benzilic acid-(1-ethyl-[4]piperidyl ester)

1-ethyl-4-benzhydryloxy-piperidine

1-Aethyl-4-chlor-piperidin

1-ethyl-1,2,5,6-tetrahydropyridine