benzilic acid-(1-ethyl-[4]piperidyl ester)

Base Information

• Chemical Name: benzilic acid-(1-ethyl-[4]piperidyl ester)
• CAS No.: 28789-59-5
• Molecular Formula: C₂₁H₂₅NO₃
• Molecular Weight: 339.434
• Mol file: 28789-59-5.mol

Synonyms:

Chemical Property of benzilic acid-(1-ethyl-[4]piperidyl ester)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzilic acid-(1-ethyl-[4]piperidyl ester)

There total 3 articles about benzilic acid-(1-ethyl-[4]piperidyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethylpiperidin-4-ol (3518-83-0) + methyl benzilate (76-89-1) → benzilic acid-(1-ethyl-[4]piperidyl ester) (28789-59-5)

Guidance literature:

With ethanol; sodium ethanolate; at 110 - 120 ℃; under 80 Torr;

Reference yield:

N-ethyl-4-piperidone (3612-18-8) → benzilic acid-(1-ethyl-[4]piperidyl ester) (28789-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Raney nickel; ethanol / 125 °C / 102971 Torr / Hydrogenation

2: 140 - 160 °C / anschliessenden Erwaermen des Reaktionsprodukts mit Wasser

With ethanol; nickel;

DOI:10.1021/ja01596a040

Reference yield:

1-ethylpiperidin-4-ol (3518-83-0) + 2-chloro-2,2-diphenylacetyl chloride (2902-98-9) → benzilic acid-(1-ethyl-[4]piperidyl ester) (28789-59-5)

Guidance literature:

at 140 - 160 ℃; anschliessenden Erwaermen des Reaktionsprodukts mit Wasser;

DOI:10.1021/ja01596a040

upstream raw materials:

1-ethylpiperidin-4-ol

methyl benzilate

2-chloro-2,2-diphenylacetyl chloride

N-ethyl-4-piperidone

Downstream raw materials:

1-ethyl-4-benziloyloxy-1-methyl-piperidinium; iodide