Hippurohydroxamic acid

Base Information

• Chemical Name: Hippurohydroxamic acid
• CAS No.: 1499-54-3
• Molecular Formula: C9H10 N2 O3
• Molecular Weight: 194.21
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID10164425
• Nikkaji Number: J4.075D
• Wikidata: Q83033501
• ChEMBL ID: CHEMBL4088851
• Mol file: 1499-54-3.mol

Synonyms:benzoylaminoacetohydroxamic acid;hippurohydroxamic acid

Chemical Property of Hippurohydroxamic acid

Chemical Property:

• Refractive Index: 1.5600 (estimate)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 85.41000
• Density: 1.296g/cm³
• LogP: 1.33690
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 194.06914219
• Heavy Atom Count: 14
• Complexity: 212

Purity/Quality:

99% ^*data from raw suppliers

HIPPUROHYDROXAMIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)NCC(=O)NO

Technology Process of Hippurohydroxamic acid

There total 13 articles about Hippurohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C28H22ClN2O3Pol → N-[2-(hydroxyamino)-2-oxoethyl]benzamide (1499-54-3)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane;

DOI:10.1080/07391102.2021.2001378

Reference yield:

C17H15N2O4Pol → N-[2-(hydroxyamino)-2-oxoethyl]benzamide (1499-54-3)

Guidance literature:

With hydroxylamine; sodium hydroxide; In water; isopropyl alcohol; for 15h; Inert atmosphere; solid phase reaction;

DOI:10.1016/j.tetlet.2011.10.103

Reference yield:

ethyl hippurate (1499-53-2) → N-[2-(hydroxyamino)-2-oxoethyl]benzamide (1499-54-3)

Guidance literature:

With potassium hydroxide; hydroxylamine;

DOI:10.1207/S15324796ABM2302_3

upstream raw materials:

ethyl hippurate

benzoyl chloride

Hippuric Acid

water

Downstream raw materials:

N-Benzoyl-glycyl-glycyl-hydroxamsaeure

N-[(benzoylamino)acetyl]glycine ethyl ester

Refernces

• 1、 Bello, Martiniano,de Pedro, Nuria,Correa-Basurto, José,Gómez-Vidal, José Antonio,Rosales-Hernández, Martha Cecilia,Sixto-López, Yudibeth. "In silico design of HDAC6 inhibitors with neuroprotective effects". . . Retrieved 2021/11/24.
• 2、 Nandurkar, Nitin S.,Petersen, Rico,Qvortrup, Katrine,Komnatnyy, Vitaly V.,Taveras, Kennedy M.,Le Quement, Sebastian T.,Frauenlob, Robin,Givskov, Michael,Nielsen, Thomas E.. "A convenient procedure for the solid-phase synthesis of hydroxamic acids on PEGA resins". supporting information; experimental part. p. 7121 - 7124. Retrieved 2012/01/14.