2-Amino-5,5,5-trifluoropentanoic acid, 2-Amino-5,5,5-trifluorovaleric acid

Base Information

• Chemical Name: 2-Amino-5,5,5-trifluoropentanoic acid, 2-Amino-5,5,5-trifluorovaleric acid
• CAS No.: 2365-80-2
• Molecular Formula: C5H8 F3 N O2
• Molecular Weight: 171.119
• Hs Code.: 2922498590
• Mol file: 2365-80-2.mol

Synonyms:2-Amino-5,5,5-trifluoropentanoicacid; NSC 76293

Chemical Property of 2-Amino-5,5,5-trifluoropentanoic acid, 2-Amino-5,5,5-trifluorovaleric acid

Chemical Property:

• Melting Point: 254-256 °C
• Boiling Point: 206.7°Cat760mmHg
• PKA: 2.17±0.10(Predicted)
• Flash Point: 78.8°C
• PSA: 63.32000
• Density: 1.356g/cm³
• LogP: 1.44110
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5,5,5-Trifluoronorvaline 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-5,5,5-trifluoropentanoic acid, 2-Amino-5,5,5-trifluorovaleric acid

There total 9 articles about 2-Amino-5,5,5-trifluoropentanoic acid, 2-Amino-5,5,5-trifluorovaleric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-acetyl-5,5,5-trifluoronorvaline (96563-56-3) → 2-amino-5,5,5-trifluoropentanoic acid (2365-80-2,23809-57-6)

Guidance literature:

With hydrogenchloride; for 20h; Heating;

DOI:10.1021/jo00280a014

Reference yield: 73.0%

5,5,5-Trifluoro-2-[(Z)-hydroxyimino]-pentanoic acid (118311-19-6) → 2-amino-5,5,5-trifluoropentanoic acid (2365-80-2,23809-57-6)

Guidance literature:

With hydrogen; platinum(IV) oxide;

DOI:10.1016/S0040-4039(00)99373-0

Reference yield:

5-(3,3,3-trifluoropropyl)imidazolidine-2,4-dione (23809-63-4) → 2-amino-5,5,5-trifluoropentanoic acid (2365-80-2,23809-57-6)

Guidance literature:

With barium dihydroxide;

DOI:10.1021/jo00830a039

upstream raw materials:

5-(3,3,3-trifluoropropyl)imidazolidine-2,4-dione

N-acetyl-5,5,5-trifluoronorvaline

5,5,5-Trifluoro-2-[(Z)-hydroxyimino]-pentanoic acid

diethyl α-(N-acetylamino)-α-(3,3,3-trifluoropropyl)malonate

Downstream raw materials:

(S)-2-amino-5,5,5-trifluoropentanoic acid

(2R)-2-amino-5,5,5-trifluoropentanoic acid

2-(benzylamino)-5,5,5-trifluoropentanoic acid

Refernces

• 1、 -. "MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF". . . Retrieved 2018/11/22.
• 2、 -. "Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof". . . Retrieved 2008/06/13.