2-(benzylamino)-5,5,5-trifluoropentanoic acid

Base Information

Chemical Name:2-(benzylamino)-5,5,5-trifluoropentanoic acid
CAS No.:1859-47-8
Molecular Formula:C₁₂H₁₄F₃NO₂
Molecular Weight:261.244
Hs Code.:

Synonyms:2-(benzylamino)-5,5,5-trifluoropentanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(benzylamino)-5,5,5-trifluoropentanoic acid

Chemical Property:

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Technology Process of 2-(benzylamino)-5,5,5-trifluoropentanoic acid

There total 2 articles about 2-(benzylamino)-5,5,5-trifluoropentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(benzylamino)-5,5,5-trifluoropentanenitrile

: 1859-47-8
2-(benzylamino)-5,5,5-trifluoropentanoic acid

Guidance literature:: With hydrogenchloride; acetic acid; In water; at 95 ℃; for 17h;

Reference yield:

: 2365-80-2,23809-57-6
2-amino-5,5,5-trifluoropentanoic acid

: 100-52-7
benzaldehyde

: 1859-47-8
2-(benzylamino)-5,5,5-trifluoropentanoic acid

Guidance literature:: Multistep reaction; (i) KOH, (ii) H₂, Pd-C;
DOI:10.1021/jm00328a014

Reference yield:

: 1859-47-8
2-(benzylamino)-5,5,5-trifluoropentanoic acid

: (R)-2-(benzyloxycarbonylamino)-5,5,5-trifluoropentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; 20% palladium hydroxide-activated charcoal / 17 h / 30 °C

2: sodium hydrogencarbonate / acetone; water / 2 h / Cooling with ice

With 20% palladium hydroxide-activated charcoal; sodium hydrogencarbonate; acetic acid; In water; acetone;