(6α,10β,11α)-Ophiobola-2,7,19-trien-21-oic acid

Base Information

Chemical Name:(6α,10β,11α)-Ophiobola-2,7,19-trien-21-oic acid
CAS No.:24433-10-1
Molecular Formula:C₂₅H₃₈O₂
Molecular Weight:370.576
Hs Code.:
Mol file:24433-10-1.mol

Synonyms:6a,10b,11a-Ophiobola-2,7,19-trien-21-oic acid (8CI); Ophiobola-2,7,19-trien-21-oicacid, (6a,10b,11a,19E)-; Dicyclopenta[a,d]cyclooctene, ophiobola-2,7,19-trien-21-oic acidderiv.; 2-Heptenoic acid,6-(1,2,3,3a,4,6a,7,8,10,10a-decahydro-6,9,10a-trimethyldicyclopenta[a,d]cycloocten-3-yl)-2-methyl-,[3R-[3a(2E,6S*),3aa,6ab,10ab]]-; Albolic acid

Suppliers and Price of (6α,10β,11α)-Ophiobola-2,7,19-trien-21-oic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of (6α,10β,11α)-Ophiobola-2,7,19-trien-21-oic acid

Chemical Property:

Boiling Point:498.9±14.0 °C(Predicted)
PKA:5.01±0.19(Predicted)
Density:1.03±0.1 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (6α,10β,11α)-Ophiobola-2,7,19-trien-21-oic acid

There total 26 articles about (6α,10β,11α)-Ophiobola-2,7,19-trien-21-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 120354-85-0,122356-56-3
ethyl albolate

: 24433-10-1,119817-57-1
albolic acid

Guidance literature:: With sodium hydroxide; In methanol; for 1h; Heating;

Reference yield:

: 120410-13-1
(R)-2-{(1R,2R,3S)-3-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-2-hydroxymethyl-3-methyl-cyclopentyl}-propan-1-ol

: 24433-10-1,119817-57-1
albolic acid

Guidance literature:: Multi-step reaction with 18 steps

1: 89 percent / pyridine

2: 95 percent / pyridine

3: H₂ / Pd/C

4: (COCl)2, DMSO, Et₃N / CH₂Cl₂

5: 98 percent / Et₃N / CH₂Cl₂

6: 94 percent / Pd(OAc)2 / acetonitrile

7: 93 percent / NaBH₄, CeCl₃ / methanol

8: 93 percent / (COCl)2, DMSO, Et₃N / CH₂Cl₂

9: 95 percent / TiCl₄, Zn / tetrahydrofuran

10: 93 percent / pyridine

11: 76 percent / Li, liq. NH₃ / ethanol

12: pyridine

13: 2.) NaCN / 1.) DMF; 2.) DMSO

15: lithium aluminum hydride / tetrahydrofuran

16: (COCl)2, DMSO, Et₃N / CH₂Cl₂

17: 93 percent / benzene

18: 95 percent / 3M NaOH / methanol

With pyridine; palladium diacetate; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; cerium(III) chloride; oxalyl dichloride; sodium cyanide; ammonia; hydrogen; titanium tetrachloride; lithium; dimethyl sulfoxide; triethylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile; benzene;
DOI:10.1039/c39880000354

Reference yield:

: 120354-77-0
2,2-Dimethyl-propionic acid (R)-2-{(1R,2R,3S)-3-[(S)-5-((R)-2-benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-2-hydroxymethyl-3-methyl-cyclopentyl}-propyl ester

: 24433-10-1,119817-57-1
albolic acid

Guidance literature:: Multi-step reaction with 17 steps

1: 95 percent / pyridine

2: H₂ / Pd/C

3: (COCl)2, DMSO, Et₃N / CH₂Cl₂

4: 98 percent / Et₃N / CH₂Cl₂

5: 94 percent / Pd(OAc)2 / acetonitrile

6: 93 percent / NaBH₄, CeCl₃ / methanol

7: 93 percent / (COCl)2, DMSO, Et₃N / CH₂Cl₂

8: 95 percent / TiCl₄, Zn / tetrahydrofuran

9: 93 percent / pyridine

10: 76 percent / Li, liq. NH₃ / ethanol

11: pyridine

12: 2.) NaCN / 1.) DMF; 2.) DMSO

14: lithium aluminum hydride / tetrahydrofuran

15: (COCl)2, DMSO, Et₃N / CH₂Cl₂

16: 93 percent / benzene

17: 95 percent / 3M NaOH / methanol

With pyridine; palladium diacetate; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; cerium(III) chloride; oxalyl dichloride; sodium cyanide; ammonia; hydrogen; titanium tetrachloride; lithium; dimethyl sulfoxide; triethylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile; benzene;
DOI:10.1039/c39880000354