(R)-2-{(1R,2R,3S)-3-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-2-hydroxymethyl-3-methyl-cyclopentyl}-propan-1-ol

Base Information

• Chemical Name: (R)-2-{(1R,2R,3S)-3-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-2-hydroxymethyl-3-methyl-cyclopentyl}-propan-1-ol
• CAS No.: 120410-13-1
• Molecular Formula: C₂₇H₄₂O₃
• Molecular Weight: 414.629
• Mol file: 120410-13-1.mol

Synonyms:(R)-2-{(1R,2R,3S)-3-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-2-hydroxymethyl-3-methyl-cyclopentyl}-propan-1-ol

Chemical Property of (R)-2-{(1R,2R,3S)-3-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-2-hydroxymethyl-3-methyl-cyclopentyl}-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-{(1R,2R,3S)-3-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-2-hydroxymethyl-3-methyl-cyclopentyl}-propan-1-ol

There total 4 articles about (R)-2-{(1R,2R,3S)-3-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-2-hydroxymethyl-3-methyl-cyclopentyl}-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,2-Dimethyl-propionic acid (1R,2S,5R)-2-[(S)-5-((R)-2-benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-5-((R)-2-hydroxy-1-methyl-ethyl)-2-methyl-cyclopentylmethyl ester (122347-09-5) + 2,2-Dimethyl-propionic acid (1R,2S,5R)-2-[(S)-5-((R)-2-benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-5-[(R)-2-(2,2-dimethyl-propionyloxy)-1-methyl-ethyl]-2-methyl-cyclopentylmethyl ester (122347-02-8) → (R)-2-{(1R,2R,3S)-3-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-2-hydroxymethyl-3-methyl-cyclopentyl}-propan-1-ol (120410-13-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield: 95.0%

(3R,4R,4aR,7S)-7-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-4,7-dimethyl-3,4,4a,5,6,7-hexahydro-cyclopenta[c]pyran-3-ol (122407-52-7) → (R)-2-{(1R,2R,3S)-3-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-2-hydroxymethyl-3-methyl-cyclopentyl}-propan-1-ol (120410-13-1)

Guidance literature:

With sodium tetrahydroborate; sodium hydrogencarbonate; In methanol; at 0 - 5 ℃; for 1h;

Reference yield:

{(3R,4R,4aR,7S)-7-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-4,7-dimethyl-3,4,4a,5,6,7-hexahydro-cyclopenta[c]pyran-3-yloxy}-trimethyl-silane (120410-12-0) → (R)-2-{(1R,2R,3S)-3-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-2-hydroxymethyl-3-methyl-cyclopentyl}-propan-1-ol (120410-13-1)

Guidance literature:

With sodium tetrahydroborate; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; Yield given. Multistep reaction; 1.) aq. THF; 2.) H₂O, MeOH;

DOI:10.1039/c39880000354

upstream raw materials:

2,2-Dimethyl-propionic acid (1R,2S,5R)-2-[(S)-5-((R)-2-benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-5-((R)-2-hydroxy-1-methyl-ethyl)-2-methyl-cyclopentylmethyl ester

2,2-Dimethyl-propionic acid (1R,2S,5R)-2-[(S)-5-((R)-2-benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-5-[(R)-2-(2,2-dimethyl-propionyloxy)-1-methyl-ethyl]-2-methyl-cyclopentylmethyl ester

(3R,4R,4aR,7S)-7-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-4,7-dimethyl-3,4,4a,5,6,7-hexahydro-cyclopenta[c]pyran-3-ol

{(3S,4R,4aR,7S)-7-[(S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-4,7-dimethyl-3,4,4a,5,6,7-hexahydro-cyclopenta[c]pyran-3-yloxy}-trimethyl-silane

Downstream raw materials:

2,2-Dimethyl-propionic acid (R)-2-[(1R,2R,3S)-3-[(S)-5-((R)-2-benzyloxy-1-methyl-ethyl)-2-methyl-cyclopent-1-enylmethyl]-2-(2-chloro-acetoxymethyl)-3-methyl-cyclopentyl]-propyl ester

Toluene-4-sulfonic acid (R)-2-((Z)-(3S,3aR,6aS,10aS)-6,9,10a-trimethyl-1,2,3,3a,4,6a,7,8,10,10a-decahydro-dicyclopenta[a,d]cycloocten-3-yl)-propyl ester

albolic acid

ceroplastol II