Pyrrolo[1,2-a]pyrazine

Base Information

• Chemical Name: Pyrrolo[1,2-a]pyrazine
• CAS No.: 274-45-3
• Molecular Formula: C7H6N2
• Molecular Weight: 118.14
• Hs Code.: 2933990090
• UNII: XV62N5YA33
• DSSTox Substance ID: DTXSID00451997
• Nikkaji Number: J757.742G
• Wikidata: Q82272337
• Metabolomics Workbench ID: 46114
• Mol file: 274-45-3.mol

Synonyms:Pyrrolo[1,2-a]pyrazine;274-45-3;7-Azaindolizine;Pyrrolo(1,2-a)pyrazine;XV62N5YA33;3a,6-Diazaindene;2'-deoxy-5-fluoro-uridine;UNII-XV62N5YA33;SCHEMBL65595;2'-Deoxy-5'-fluoro-Uridine;5-FLUORO DEOXY URIDINE;DTXSID00451997;CHEBI:193615;AMY36708;MFCD01605573;AKOS006275889;CS-W006655;DS-11786;A5324;diethyl4-(2-furyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property of Pyrrolo[1,2-a]pyrazine

Chemical Property:

• Refractive Index: 1.628
• Boiling Point: 71 °C(Press: 2 Torr)
• PKA: 0.90±0.10(Predicted)
• PSA: 17.30000
• Density: 1.14 g/cm³
• LogP: 1.33430
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 118.053098200
• Heavy Atom Count: 9
• Complexity: 103

Purity/Quality:

98%min ^*data from raw suppliers

Pyrrolo[1,2-a]pyrazine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C=CN=CC2=C1

Technology Process of Pyrrolo[1,2-a]pyrazine

There total 8 articles about Pyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

7-amino-3-iodomethyl-3-cephem-4-carboxylate + bis-(trimethylsilyl)acetamide (17879-45-7) → 7-azaindolizine (274-45-3) + 7-amino-3-(pyrrolo-[1,2-a]pyrazinium-2-yl)methyl-3-cephem-4-carboxylate.HI

Guidance literature:

In acetonitrile;

Reference yield: 63.0%

3,4-dihydropyrrolo[1,2-a]-pyrazine (71257-37-9) → 7-azaindolizine (274-45-3)

Guidance literature:

palladium on activated charcoal; In xylene; for 15h; Heating;

DOI:10.1007/BF01145551

Reference yield: 41.0%

→ 7-azaindolizine (274-45-3)

Guidance literature:

upstream raw materials:

(2,2-diethoxy-ethyl)-pyrrol-2-ylmethylen-amine

3,4-dihydropyrrolo[1,2-a]-pyrazine

1,2,3,4-Tetrahydropyrrolo<1,2-a>pyrazine

phosphoric acid

Downstream raw materials:

4-methylpyrrolo<1,2-a>pyrazine

Refernces

• 1、 Minguez, Jose M.,Castellote, Maria I.,Vaquero, Juan J.,Garcia-Navio, Jose L.,Alvarez-Builla, Julio,Castano, Obis,Andres, Jose L.. "Pyrrolodiazines. 2. Structure and chemistry of pyrrolo[1,2-a]pyrazine and 1,3-dipolar cycloaddition of its azomethine ylides". . p. 4655 - 4665. Retrieved 1996.
• 2、 -. "Cephalosporin derivatives". . . Retrieved 2008/06/13.