vanilglycolic acid

Base Information

• Chemical Name: vanilglycolic acid
• CAS No.: 2021-40-1
• Molecular Formula: C9H8 O5
• Molecular Weight: 196.16
• Hs Code.: 2918990090
• Mol file: 2021-40-1.mol

Synonyms:Glyoxylicacid, (4-hydroxy-3-methoxyphenyl)- (6CI,7CI,8CI);4-Hydroxy-3-methoxyphenylglyoxylic acid; Vanilloylformic acid

Chemical Property of vanilglycolic acid

Chemical Property:

• Vapor Pressure: 5.83E-07mmHg at 25°C
• Boiling Point: 395.4°Cat760mmHg
• Flash Point: 163.5°C
• PSA: 83.83000
• Density: 1.421g/cm³
• LogP: 0.66810

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of vanilglycolic acid

There total 23 articles about vanilglycolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(3-methoxy-4-hydroxyphenyl)ethanone (498-02-2) → (4-hydroxy-3-methoxy-phenyl)-glyoxylic acid (2021-40-1)

Guidance literature:

With nitrobenzene; sodium hydroxide; In water; at 100 ℃; for 24h;

DOI:10.3390/molecules24091794

Reference yield: 72.0%

methyl 2-(4-hydroxy-3-methoxyphenyl)-2-oxoacetate → (4-hydroxy-3-methoxy-phenyl)-glyoxylic acid (2021-40-1)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2009.11.035

Reference yield:

nitrobenzene (98-95-3,26969-40-4) + 1-(3-methoxy-4-hydroxyphenyl)ethanone (498-02-2) → (4-hydroxy-3-methoxy-phenyl)-glyoxylic acid (2021-40-1)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01325a033 DOI:10.1021/ja01314a507 DOI:10.1007/BF02766093

upstream raw materials:

1-(4-hydroxy-3-methoxy-phenyl)-propane-1,2-dione

eugenol acetate

3,4-dimethoxyphenylglyoxylic acid

(E)-1-(4-acetoxy-3-methoxyphenyl)-1-propene

Downstream raw materials:

vanillin

carbon dioxide

3-methoxy-4-hydroxy mandelic acid

3-methoxy-4-hydroxybenzonitrile