1,2,3-Oxadiazolium, 5-amino-3-(4-methylphenyl)-, chloride

Base Information

• Chemical Name: 1,2,3-Oxadiazolium, 5-amino-3-(4-methylphenyl)-, chloride
• CAS No.: 6162-49-8
• Molecular Formula: C9H10N3O.Cl
• Molecular Weight: 211.651
• Mol file: 6162-49-8.mol

Synonyms:

Chemical Property of 1,2,3-Oxadiazolium, 5-amino-3-(4-methylphenyl)-, chloride

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3-Oxadiazolium, 5-amino-3-(4-methylphenyl)-, chloride

There total 3 articles about 1,2,3-Oxadiazolium, 5-amino-3-(4-methylphenyl)-, chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

p-tolylaminoacetonitrile (16728-84-0) → 5-amino-3-(p-tolyl)-1,2,3-oxadiazol-3-ium chloride (6162-49-8)

Guidance literature:

p-tolylaminoacetonitrile; With isopentyl nitrite; In diethyl ether; at 20 ℃; for 20h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c02982

Reference yield:

p-toluidine (106-49-0,12221-03-3) → 5-amino-3-(p-tolyl)-1,2,3-oxadiazol-3-ium chloride (6162-49-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide; potassium carbonate / acetonitrile / 3 h / Reflux

2: n-Amyl nitrite / diethyl ether / 20 h / 20 °C

With n-Amyl nitrite; potassium carbonate; sodium iodide; In diethyl ether; acetonitrile;

DOI:10.1002/anie.201708790

Reference yield:

N-Nitroso-N-(4-methyl-phenylamino)-acetonitril (829-28-7) → 5-amino-3-(p-tolyl)-1,2,3-oxadiazol-3-ium chloride (6162-49-8)

Guidance literature:

With hydrogenchloride; In diethyl ether; Yield given;

DOI:10.1080/00397919208019267

upstream raw materials:

N-Nitroso-N-(4-methyl-phenylamino)-acetonitril

p-tolylaminoacetonitrile

p-toluidine

Downstream raw materials:

5-acetylamino-3-p-tolyl-[1,2,3]oxadiazolium betaine

Refernces

• 1、 Riomet, Margaux,Decuypere, Elodie,Porte, Karine,Bernard, Sabrina,Plougastel, Lucie,Kolodych, Sergii,Audisio, Davide,Taran, Frédéric. "Design and Synthesis of Iminosydnones for Fast Click and Release Reactions with Cycloalkynes". supporting information. p. 8535 - 8541. Retrieved 2018/05/30.
• 2、 Beal,Turnbull. "An efficient, one-pot synthesis of 3-alkyl or aryl sydnoneimines". . p. 673 - 676. Retrieved 2007/10/02.