ethyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate

Base Information

• Chemical Name: ethyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate
• CAS No.: 61675-94-3
• Molecular Formula: C9H16O4
• Molecular Weight: 188.224
• European Community (EC) Number: 612-188-7
• DSSTox Substance ID: DTXSID10447629
• Nikkaji Number: J2.318.744B
• Mol file: 61675-94-3.mol

Synonyms:61675-94-3;ethyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate;Ethyl 2-(oxan-2-yloxy)acetate;ethyl (tetrahydro-2H-pyran-2-yloxy)acetate;Acetic acid, [(tetrahydro-2H-pyran-2-yl)oxy]-, ethyl ester;ethyl 2-(tetrahydro-2H-pyran-2-yloxy)acetate;[(Tetrahydropyran-2-yl)oxy]acetic acid ethyl ester;SCHEMBL374442;DTXSID10447629;GZVWKAGBBACFPD-UHFFFAOYSA-N;ethyl (tetrahydropyranyloxy)acetate;MFCD00128492;AKOS028108831;Ethyl(tetrahydropyran-2-yloxy)-acetate;ethyl 2-(2-tetrahydropyranyloxy)acetate;DS-19244;CS-0151565;Ethyl-2-(tetrahydro-2H-pyran-2-yloxy)acetate;ethyl2-((tetrahydro-2H-pyran-2-yl)oxy)acetate;O11739;(tetrahydropyran-2-yloxy)acetic acid ethyl ester;(tetrahydropyran-2-yloxy)-acetic acid ethyl ester;(Tetrahydro-2H-pyran-2-yloxy)acetic acid ethyl ester

Chemical Property of ethyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate

Chemical Property:

• Vapor Pressure: 0.00321mmHg at 25°C
• Refractive Index: 1.4440 (589.3 nm 16℃)
• Boiling Point: 283.2oC at 760 mmHg
• Flash Point: 121.8oC
• PSA: 44.76000
• Density: 1.07g/cm3
• LogP: 1.09270
• Storage Temp.: 2-8°C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 188.10485899
• Heavy Atom Count: 13
• Complexity: 158

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-((Tetrahydro-2H-pyran-2-yl)oxy)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)COC1CCCCO1
• Uses: Ethyl 2-((Tetrahydro-2H-pyran-2-yl)oxy)acetate has been used as a reactant for the sysnthesis of 3-phenylpyrazolo[1,5-a]pyrimidine as a potent corticotropin-releasing factor-1 antagonist.

Technology Process of ethyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate

There total 3 articles about ethyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,4-dihydro-2H-pyran (110-87-2) + ethyl 2-hydroxyacetate (623-50-7) → ethyl (tetrahydropyranyloxy)acetate (61675-94-3)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 25 ℃; for 1h;

Reference yield: 85.0%

→ ethyl (tetrahydropyranyloxy)acetate (61675-94-3)

Guidance literature:

Reference yield:

TETRAHYDROPYRANE (142-68-7) + ethyl 2-hydroxyacetate (623-50-7) → ethyl (tetrahydropyranyloxy)acetate (61675-94-3)

Guidance literature:

With toluene-4-sulfonic acid; at 20 ℃;

upstream raw materials:

3,4-dihydro-2H-pyran

ethyl 2-hydroxyacetate

TETRAHYDROPYRANE

Downstream raw materials:

((2R,3R,5S,6R)-6-Benzyloxymethyl-2-hydroxy-5-methoxy-3-methyl-tetrahydro-pyran-2-yl)-[(tetrahydro-pyran-2-yloxy)]-acetic acid ethyl ester

2-phenyl-5-(tetrahydro-2-pyranyloxy)-4-pyrimidinone

5-hydroxy-2-methyl-(3H)-pyrimidin-4-one

(E)-2-styryl-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4-yl trifluoromethanesulfonate