2-[(3-chlorobenzyl)sulfanyl]-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one

Base Information

Chemical Name:2-[(3-chlorobenzyl)sulfanyl]-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one
CAS No.:1417817-45-8
Molecular Formula:C₁₆H₁₇ClN₂O₃S
Molecular Weight:352.842
Hs Code.:

Synonyms:2-[(3-chlorobenzyl)sulfanyl]-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one

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Chemical Property of 2-[(3-chlorobenzyl)sulfanyl]-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one

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Technology Process of 2-[(3-chlorobenzyl)sulfanyl]-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one

There total 3 articles about 2-[(3-chlorobenzyl)sulfanyl]-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 61675-94-3
ethyl (tetrahydropyranyloxy)acetate

: 169558-97-8
3-chlorobenzyl carbamimidothioate hydrobromide

: 109-94-4
formic acid ethyl ester

: 1417817-45-8
2-[(3-chlorobenzyl)sulfanyl]-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one

Guidance literature:: ethyl (tetrahydropyranyloxy)acetate; formic acid ethyl ester; With sodium hydride; In diethyl ether; mineral oil; for 2h; Reflux;

3-chlorobenzyl carbamimidothioate hydrobromide; In ethanol; mineral oil; for 4h; Reflux;

Reference yield: 28.0%

: 61675-94-3
ethyl (tetrahydropyranyloxy)acetate

: 3-chlorobenzyl carbamidothioate hydrobromide

: 109-94-4
formic acid ethyl ester

: 1417817-45-8
2-[(3-chlorobenzyl)sulfanyl]-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one

Guidance literature:: ethyl (tetrahydropyranyloxy)acetate; formic acid ethyl ester; With sodium hydride; In diethyl ether; Reflux;

3-chlorobenzyl carbamidothioate hydrobromide; In ethanol; for 4h; Reflux;

Reference yield:

: 766-80-3
1-bromomethyl-3-chlorobenzene

: 1417817-45-8
2-[(3-chlorobenzyl)sulfanyl]-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / Reflux

2.1: sodium hydride / diethyl ether; mineral oil / 2 h / Reflux

2.2: 4 h / Reflux

With sodium hydride; In diethyl ether; ethanol; mineral oil;