2-Chloro-1-(4-iodophenyl)ethanone

Base Information

• Chemical Name: 2-Chloro-1-(4-iodophenyl)ethanone
• CAS No.: 4209-04-5
• Molecular Formula: C8H6ClIO
• Molecular Weight: 280.493
• Hs Code.: 2914700090
• DSSTox Substance ID: DTXSID40368959
• Nikkaji Number: J2.192.382F
• Wikidata: Q82155877
• Mol file: 4209-04-5.mol

Synonyms:2-chloro-1-(4-iodophenyl)ethanone;4209-04-5;2-chloro-1-(4-iodophenyl)ethan-1-one;2-chloro-4'-iodoacetophenone;SCHEMBL2476630;alpha-Chloro-4'-iodoacetophenone;DTXSID40368959;LJKQIBWZNUCGSG-UHFFFAOYSA-N;MFCD06366756;AKOS008967728;CS-0223315;EN300-11473;Z57046985

Chemical Property of 2-Chloro-1-(4-iodophenyl)ethanone

Chemical Property:

• Vapor Pressure: 0.000234mmHg at 25°C
• Melting Point: 148-150 °C
• Boiling Point: 325.2°Cat760mmHg
• Flash Point: 150.5°C
• PSA: 17.07000
• Density: 1.816g/cm³
• LogP: 2.71270
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 279.91519
• Heavy Atom Count: 11
• Complexity: 141

Purity/Quality:

98% ^*data from raw suppliers

2-CHLORO-1-(4-IODOPHENYL)ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)CCl)I

Technology Process of 2-Chloro-1-(4-iodophenyl)ethanone

There total 5 articles about 2-Chloro-1-(4-iodophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-(4-iodophenyl)ethanol (68120-56-9,104013-25-4,53207-29-7) → 2-chloro-1-(4-iodophenyl)ethan-1-one (4209-04-5)

Guidance literature:

With methanol; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ol5024568

Reference yield: 73.0%

2-diazo-1-(4-iodophenyl)ethanone (52470-94-7) → 2-chloro-1-(4-iodophenyl)ethan-1-one (4209-04-5)

Guidance literature:

With iron(III) chloride; silica gel; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2018.02.024

Reference yield:

iodobenzene (591-50-4) + chloroacetyl chloride (79-04-9) → 2-chloro-1-(4-iodophenyl)ethan-1-one (4209-04-5)

Guidance literature:

With aluminium trichloride; In dichloromethane;

DOI:10.1016/j.tetasy.2003.09.035

upstream raw materials:

1-(4-(dichloro-λ³-iodanyl)phenyl)ethan-1-one

iodobenzene

chloroacetyl chloride

1-(4-iodophenyl)ethanol

Downstream raw materials:

4-[4-(4-iodo-phenyl)-thiazol-2-ylamino]-benzenesulfonamide

4-[4-(4-iodo-phenyl)-thiazol-2-ylamino]-3-methyl-benzenesulfonamide

4-[4-(4-iodo-phenyl)-thiazol-2-ylamino]-2-methyl-benzenesulfonamide

2-[4-(4-iodo-phenyl)-thiazol-2-ylamino]-5-methyl-benzenesulfonamide