4,5-DICHLORO-2-NITROTOLUENE

Base Information

• Chemical Name: 4,5-DICHLORO-2-NITROTOLUENE
• CAS No.: 7494-45-3
• Molecular Formula: C7H5Cl2NO2
• Molecular Weight: 206.028
• Hs Code.: 2904909090
• Mol file: 7494-45-3.mol

Synonyms:2-Methyl-4,5-dichloronitrobenzene;3,4-Dichloro-6-nitrotoluene;4,5-Dichloro-2-nitrotoluene;1,2-Dichloro-4-methyl-5-nitrobenzene;

Chemical Property of 4,5-DICHLORO-2-NITROTOLUENE

Chemical Property:

• Vapor Pressure: 0.00778mmHg at 25°C
• Melting Point: 62 °C
• Refractive Index: 1.585
• Boiling Point: 277.1 °C at 760 mmHg
• Flash Point: 121.4 °C
• PSA: 45.82000
• Density: 1.456 g/cm³
• LogP: 3.73320
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99%, ^*data from raw suppliers

3,4-Dichloro-6-nitrotoluene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,4-Dichloro-6-nitrotoluene is used as a reagent in the synthesis of N-hydroxyindole-2-carboxylates as inhibitors of lactate dehydrogenase against cancer cell proliferation. 3,4-Dichloro-6-nitrotoluene is also used in the preparation of polyhalogenated quinoline C-nucleosides as potential antiviral agents.This compound is suitable for lactate dehydrogenase (LDH) related research.

Technology Process of 4,5-DICHLORO-2-NITROTOLUENE

There total 5 articles about 4,5-DICHLORO-2-NITROTOLUENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4-Dichlorotoluene (95-75-0) → 1,2-dichloro-4-methyl-5-nitrobenzene (7494-45-3)

Guidance literature:

With nitric acid; at 0 - 20 ℃; for 2h;

Reference yield: 60.0%

2,4,5-Trichloronitrobenzene (89-69-0) + sodium diethylmalonate (996-82-7) → 1,2-dichloro-4-methyl-5-nitrobenzene (7494-45-3) + 2,5-dichloro-4-nitrotoluene (7149-76-0)

Guidance literature:

2,4,5-Trichloronitrobenzene; sodium diethylmalonate; In N,N-dimethyl-formamide; at 20 ℃;

With dimethyl sulfoxide; sodium chloride; at 160 - 170 ℃; for 12h;

DOI:10.1055/s-2000-8209

Reference yield:

→ 1,2-dichloro-4-methyl-5-nitrobenzene (7494-45-3)

Guidance literature:

With copper(l) chloride;

upstream raw materials:

3,4-Dichlorotoluene

2,5-dinitro-4-methylaniline

2-chloro-5-methyl-4-nitroaniline

2,4,5-Trichloronitrobenzene

Downstream raw materials:

2-nitro-4-chloro-5-methoxymethylbenzene

4,5-or4,6-dichloro-2-amino-toluene

4,5-dichloro-2-nitrobenzoic acid

5,6-dichloro-1H-indole

Refernces

• 1、 -. "METHODS USING HDAC11 INHIBITORS". Paragraph 0639-0640. . Retrieved 2018/05/16.
• 2、 -. "BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR". Page/Page column 33-34. . Retrieved 2010/11/25.