3,4-Dimethoxyphenylglyoxal hydrate

Base Information

• Chemical Name: 3,4-Dimethoxyphenylglyoxal hydrate
• CAS No.: 163428-90-8
• Molecular Formula: C10H12O5
• Molecular Weight: 212.202
• Mol file: 163428-90-8.mol

Synonyms:3,4-DIMETHOXYPHENYLGLYOXAL HYDRATE;3,4-Dimethoxyphenylglyoxal hydrate 95%;3,4-DIMETHOXYPHENYLGLYOXAL HYDRATE , DRY WT. BASIS;3,4-DIMETHOXYPHENYLGLYOXAL HYDRATE, 98%, DRY WT BASIS

Chemical Property of 3,4-Dimethoxyphenylglyoxal hydrate

Chemical Property:

• Vapor Pressure: 0.000761mmHg at 25°C
• Melting Point: 118-120 °C
• Refractive Index: 1.511
• Boiling Point: 387 °C at 760 mmHg
• PKA: 10.88±0.41(Predicted)
• Flash Point: 187.9 °C
• PSA: 61.83000
• Density: 1.167g/cm³
• LogP: 1.02110

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dimethoxyphenylglyoxalhydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Dimethoxyphenylglyoxal hydrate

There total 3 articles about 3,4-Dimethoxyphenylglyoxal hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3,4-dimethoxyphenyl)ethanone (1131-62-0) → 2,2-dihydroxy-1-(3,4-dimethoxyphenyl)ethan-1-one (163428-90-8)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; water; for 40h; Heating;

DOI:10.1246/bcsj.55.3865

Reference yield:

1,2-dimethoxybenzene (91-16-7) → 2,2-dihydroxy-1-(3,4-dimethoxyphenyl)ethan-1-one (163428-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric acid / 1 h / 40 - 50 °C

2: selenium dioxide / dioxane; H₂O / 40 h / Heating

With selenium(IV) oxide; PPA; In 1,4-dioxane; water;

DOI:10.1246/bcsj.55.3865

Reference yield:

3',4'-dimethoxyphenylglyoxal (15462-03-0) → 2,2-dihydroxy-1-(3,4-dimethoxyphenyl)ethan-1-one (163428-90-8)

Guidance literature:

With water; for 5h; Reflux; Inert atmosphere;

DOI:10.1055/s-0031-1289613

upstream raw materials:

1-(3,4-dimethoxyphenyl)ethanone

1,2-dimethoxybenzene

3',4'-dimethoxyphenylglyoxal

Downstream raw materials:

1-(3,4-dimethoxyphenyl)-2-(pyrrolidin-1-yl)-2-thioxoethanone

1-(3,4-dimethoxyphenyl)-2-(piperidin-1-yl)-2-thioxoethanone

1-(3,4-dimethoxyphenyl)-2-morpholino-2-thioxoethan-1-one

(3,4‐dimethoxyphenyl)[4‐(3,4‐dimethoxyphenyl)‐1H‐imidazol‐2‐yl]methanone

Refernces

• 1、 Poursattar Marjani, Ahmad,Khalafy, Jabbar,Farajollahi, Ayda. "Synthesis of Ethyl 2-Amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates by a One-pot, Three-Component Reaction in the Presence of TPAB". . p. 268 - 274. Retrieved 2018/11/30.
• 2、 Khalafy, Jabbar,Etivand, Nasser,Poursattar Marjani, Ahmad,Khalillou, Neda. "Synthesis of 4-Hydroxy-3-(2-arylimidazo[1,2-a]pyridin-3-yl)quinolin-2(1H)-ones in the Presence of DABCO as an Efficient Organocatalyst". . p. 1857 - 1865. Retrieved 2019/05/21.