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1,2-Dimethoxybenzene

Base Information Edit
  • Chemical Name:1,2-Dimethoxybenzene
  • CAS No.:91-16-7
  • Molecular Formula:C8H10O2
  • Molecular Weight:138.166
  • Hs Code.: Oral rat LD50: 890 mg/kg
  • European Community (EC) Number:202-045-3
  • NSC Number:16934
  • UNII:61WJZ2Q41I
  • DSSTox Substance ID:DTXSID7047065
  • Nikkaji Number:J4.334F
  • Wikipedia:1,2-Dimethoxybenzene
  • Wikidata:Q131994
  • Pharos Ligand ID:3L2K3D3YAR1P
  • Metabolomics Workbench ID:45287
  • ChEMBL ID:CHEMBL1668603
  • Mol file:91-16-7.mol
1,2-Dimethoxybenzene

Synonyms:1,2-dimethoxybenzene;o-dimethoxybenzene;veratrole

Suppliers and Price of 1,2-Dimethoxybenzene
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Veratrole
  • 25 g
  • $ 65.00
  • TCI Chemical
  • 1,2-Dimethoxybenzene >99.0%(GC)
  • 25g
  • $ 17.00
  • TCI Chemical
  • 1,2-Dimethoxybenzene >99.0%(GC)
  • 100g
  • $ 30.00
  • TCI Chemical
  • 1,2-Dimethoxybenzene >99.0%(GC)
  • 500g
  • $ 73.00
  • Sigma-Aldrich
  • Pyrocatechol dimethyl ether for synthesis. CAS 91-16-7, EC Number 202-045-3, chemical formula (CH O) C H ., for synthesis
  • 8085291000
  • $ 140.00
  • Sigma-Aldrich
  • Pyrocatechol dimethyl ether for synthesis
  • 1 L
  • $ 134.12
  • Sigma-Aldrich
  • 1,2-Dimethoxybenzene ReagentPlus , 99%
  • 1kg
  • $ 116.00
  • Sigma-Aldrich
  • 1,2-Dimethoxybenzene ReagentPlus , 99%
  • 500g
  • $ 78.20
  • Sigma-Aldrich
  • 1,2-Dimethoxybenzene ≥99%, FG
  • 5kg
  • $ 299.00
  • Sigma-Aldrich
  • Pyrocatechol dimethyl ether for synthesis
  • 250 mL
  • $ 54.10
Total 182 raw suppliers
Chemical Property of 1,2-Dimethoxybenzene Edit
Chemical Property:
  • Appearance/Colour:clear colourless liquid after melting 
  • Vapor Pressure:0.344mmHg at 25°C 
  • Melting Point:15 °C(lit.) 
  • Refractive Index:n20/D 1.533(lit.)  
  • Boiling Point:206.3 °C at 760 mmHg 
  • Flash Point:76.6 °C 
  • PSA:18.46000 
  • Density:1.005 g/cm3 
  • LogP:1.70380 
  • Storage Temp.:Store below +30°C. 
  • Solubility.:6.69g/l insoluble 
  • Water Solubility.:Soluble in alcohol, diethyl ether, acetone, and methanol. Slightly soluble in water. 
  • XLogP3:1.6
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:2
  • Rotatable Bond Count:2
  • Exact Mass:138.068079557
  • Heavy Atom Count:10
  • Complexity:81.3
Purity/Quality:

99% *data from raw suppliers

Veratrole *data from reagent suppliers

Safty Information:
  • Pictogram(s): HarmfulXn 
  • Hazard Codes:Xn 
  • Statements: 22-20/21/22 
  • Safety Statements: 36-23-24/25 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Chemical Classes:Other Classes -> Ethers, Other
  • Canonical SMILES:COC1=CC=CC=C1OC
  • Description 1, 2-Dimethoxybenzene, commonly known as veratrole, is an organic compound with the formula C6H4(OCH3)2. It is a colorless liquid with a pleasant odor and slight solubility in water. It is the dimethyl ether derived from pyrocatechol, too. 1, 2-Dimethoxybenzene is naturally occurring. Its biosynthesis entails the methylation of guaiacol by guaiacol O-methyltransferase.1, 2-Dimethoxybenzene is an insect attractant. Guaiacol O-methyltransferase gene is first scent gene discovered so far in any plant species.
  • Uses 1, 2-Dimethoxybenzene is a building block for the organic synthesis of other aromatic compounds. Veratrole is relatively electron-rich and thus readily undergoes electrophilic substitution. An example of the use of veratrole is in the synthesis of Domipizone. Veratrole can easily be brominated with NBS to give 4-bromoveratrole. Veratrole is common reagent in organic synthesis such as the synthesis of arizonins B1 and C1. Also used in the synthesis of pharmacophores of salmeterol and roflumilast as dual β2-adrenoreceptor agonists-PDE4 inhibitors. 1,2-Dimethoxybenzene was used to investigate the electroantennogram response of vine weevil, Otiorhynchus sulcatus to plant volatiles.
Technology Process of 1,2-Dimethoxybenzene

There total 136 articles about 1,2-Dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With isopropyl alcohol; at 20 ℃; for 24h; chemoselective reaction; UV-irradiation;
DOI:10.1039/C8CC08942F
Guidance literature:
With [2,2]bipyridinyl; palladium(II) trifluoroacetate; oxygen; trifluoroacetic acid; In 1,4-dioxane; dimethyl sulfoxide; at 100 ℃; for 32h;
DOI:10.1021/acs.joc.9b01162
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