5-nitro-1H-quinolin-2-one

Base Information

• Chemical Name: 5-nitro-1H-quinolin-2-one
• CAS No.: 6938-27-8
• Molecular Formula: C9H6N2O3
• Molecular Weight: 190.1555
• Hs Code.: 2933790090
• Mol file: 6938-27-8.mol

Synonyms:5-(Hydroxyl[oxido]amino)-2-hydroxyquinoline;5-Nitrocarbostyril;5-Nitroquinolin-2(1H)-one;NSC 53940;

Chemical Property of 5-nitro-1H-quinolin-2-one

Chemical Property:

• Vapor Pressure: 8.67E-07mmHg at 25°C
• Melting Point: 245-247 ℃
• Refractive Index: 1.589
• Boiling Point: 422.1 °C at 760 mmHg
• Flash Point: 209.1 °C
• PSA: 78.68000
• Density: 1.419 g/cm³
• LogP: 1.95950
• Solubility.: Methanol, Ethyl Acetate

Purity/Quality:

97% ^*data from raw suppliers

5-Nitro-1H-quinolin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Nitro-1H-quinolin-2-one is used in the synthetic preparation of novel antileishmanial agents for Leishmania donovani promastigotes.

Technology Process of 5-nitro-1H-quinolin-2-one

There total 13 articles about 5-nitro-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-5-nitro-1,2-dihydroquinoline (1116137-62-2) → 5-nitro-2<1H>quinolinone (6938-27-8)

Guidance literature:

With hydrogenchloride; In water; for 16h; Product distribution / selectivity; Heating / reflux;

Reference yield: 92.0%

2-chloro-5-nitroquinoline (13067-94-2) → 5-nitro-2<1H>quinolinone (6938-27-8)

Guidance literature:

With perchloric acid; In water; acetonitrile; at 100 ℃; for 72h;

DOI:10.1016/j.ejmech.2018.06.001

Reference yield: 87.0%

2-chloro-5-nitroquinoline (13067-94-2) → 5-nitroquinolin-2-ol (6938-27-8)

Guidance literature:

With hydrogenchloride; water; for 1h; Reflux;

DOI:10.1016/j.ejmech.2012.04.029

upstream raw materials:

5-nitroquinoline

2-chloro-5-nitroquinoline

2-bromo-5-nitroquinoline

5-nitro-quinoline-1-oxide

Downstream raw materials:

5-amino-quinolin-2-ol

2-chloro-5-nitroquinoline

2-methoxy-5-nitroquinoline

5-aminoquinolin-2(1H)-one