N-(4-hydroxy-2-nitrophenyl)acetamide

Base Information

• Chemical Name: N-(4-hydroxy-2-nitrophenyl)acetamide
• CAS No.: 7403-75-0
• Molecular Formula: C8H8N2O4
• Molecular Weight: 196.163
• Hs Code.: 2924299090
• NSC Number: 400387
• DSSTox Substance ID: DTXSID20398613
• Nikkaji Number: J1.235.989F
• Wikidata: Q82200695
• ChEMBL ID: CHEMBL1487685
• Mol file: 7403-75-0.mol

Synonyms:N-(4-hydroxy-2-nitrophenyl)acetamide;7403-75-0;3-NITRO-4-ACETAMIDOPHENOL;MLS000757165;1-Acetamido-4-hydroxy-2-nitrobenzene;4-Acetamido-3-nitrophenol;NSC400387;3-nitro-4-acetylaminophenol;SCHEMBL694246;2-Nitro-4-Hydroxy-Acetanilide;CHEMBL1487685;DTXSID20398613;OZZKMZSOGAOIFX-UHFFFAOYSA-N;HMS2886M20;AKOS006329239;N-(2-Nitro-4-hydroxyphenyl)acetamide;1 -acetamido-4-hydroxy-2-nitrobenzene;NSC-400387;SMR000529025;FT-0672742

Chemical Property of N-(4-hydroxy-2-nitrophenyl)acetamide

Chemical Property:

• Vapor Pressure: 4.74E-09mmHg at 25°C
• Melting Point: 218-220°C
• Boiling Point: 459.1°Cat760mmHg
• PKA: 8.23±0.12(Predicted)
• Flash Point: 231.5°C
• PSA: 95.15000
• Density: 1.477g/cm³
• LogP: 1.85500
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 196.04840674
• Heavy Atom Count: 14
• Complexity: 238

Purity/Quality:

99% ^*data from raw suppliers

3-Nitro-4-acetamidophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C=C(C=C1)O)[N+](=O)[O-]
• Uses: 3-Nitro-4-acetamidophenol (cas# 7403-75-0) is a compound useful in organic synthesis.

Technology Process of N-(4-hydroxy-2-nitrophenyl)acetamide

There total 11 articles about N-(4-hydroxy-2-nitrophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-acetamido-3-nitrophenyl acetate (2243-69-8) → N-(4-hydroxy-2-nitrophenyl)-acetamide (7403-75-0)

Guidance literature:

With sodium hydrogencarbonate; In methanol; for 2h; Inert atmosphere;

DOI:10.1002/adsc.201000493

Reference yield: 87.0%

4-acetaminophenol (103-90-2,8055-08-1) → N-(4-hydroxy-2-nitrophenyl)-acetamide (7403-75-0)

Guidance literature:

With ammonium molybdate; water; nitric acid; In chloroform; for 6h; Heating;

DOI:10.1246/cl.2000.48

Reference yield: 70.0%

4-acetaminophenol (103-90-2,8055-08-1) → N-(4-hydroxy-2-nitrophenyl)-acetamide (7403-75-0) + N-(4-hydroxy-3-nitrophenyl)acetamide (51288-37-0)

Guidance literature:

With sodium nitrite;

DOI:10.1021/acs.orglett.5b01837

upstream raw materials:

4-acetamido-3-nitrophenyl acetate

4-hydroxy-2-nitroaniline

acetic anhydride

4-acetaminophenol

Downstream raw materials:

Pentabromophenol

4-hydroxy-2-nitroaniline

4-acetamino-2,3-dinitrophenol

acetic acid-(4-hydroxy-2,5-dinitro-anilide)