2,3-Dibromopropylazanium;bromide

Base Information

• Chemical Name: 2,3-Dibromopropylazanium;bromide
• CAS No.: 6963-32-2
• Molecular Formula: C3H8Br3N
• Molecular Weight: 297.815
• Hs Code.: 2921199090
• Mol file: 6963-32-2.mol

Synonyms:

Chemical Property of 2,3-Dibromopropylazanium;bromide

Chemical Property:

• Vapor Pressure: 0.0924mmHg at 25°C
• Melting Point: 164 °C
• Refractive Index: 1.556
• Boiling Point: 224.2 °C at 760 mmHg
• Flash Point: 89.4 °C
• PSA: 26.02000
• Density: 1.999g/cm³
• LogP: 2.76190
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 296.81864
• Heavy Atom Count: 7
• Complexity: 32

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-Dibromo-propylamine, hydrobromide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(CBr)Br)[NH3+].[Br-]
• Uses: In tandem with Turbo Grignard (Aldrich product 656984) and an electrophilic trap, 2,3-Dibromo-propylamine hydrobromide generates a "spring loaded" electrophile, which is a convenient reagent for the installation of azetidine to secondary amines. This product is one of several synthetic useful reagents reported by Baran and coworkers on Strain-release amination.

Technology Process of 2,3-Dibromopropylazanium;bromide

There total 4 articles about 2,3-Dibromopropylazanium;bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-amino-2-propene (107-11-9,30551-89-4) → 2,3-dibromopropylamine hydrobromide (6963-32-2)

Guidance literature:

With bromine; In ethanol;

DOI:10.1016/S0040-4039(99)00603-6

Reference yield: 66.0%

1-butylene (106-98-9,9003-28-5) → 2,3-dibromopropylamine hydrobromide (6963-32-2)

Guidance literature:

With bromine; In ethanol; at 0 - 20 ℃; for 16h;

DOI:10.1021/jacs.9b01513

Reference yield:

N-tert-butoxycarbonylprop-2-en-1-amine (78888-18-3) → 2,3-dibromopropylamine hydrobromide (6963-32-2)

Guidance literature:

With bromine; In ethanol; at 0 - 20 ℃; for 16h; Inert atmosphere;

upstream raw materials:

1-amino-2-propene

1-butylene

N-tert-butoxycarbonylprop-2-en-1-amine

Downstream raw materials:

(2,3-Dibromo-propyl)-[1-p-tolyl-meth-(E)-ylidene]-amine

1-azabicyclo<1.1.0>butane

N-benzylidene-2,3-dibromopropylamine

1-Benzenesulfonyl-2-(bromomethyl)ethylenimine

Refernces

• 1、 -. "SOLID FORMS OF 3-((1R,3R)-1-(2,6-DIFLUORO-4-((1-(3-FLUOROPROPYL)AZETIDIN-3-YL)AMINO)PHENYL)-3-METHYL-1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-B]INDOL-2-YL)-2,2-DIFLUOROPROPAN-1-OL AND PROCESSES FOR PREPARING FUSED TRICYCLIC COMPOUNDS COMPRISING A SUBSTITUTED PHENYL OR PYRIDINYL MOIETY, INCLUDING METHODS OF THEIR USE". Page/Page column 0411; 0516-0518. . Retrieved 2020/01/11.
• 2、 -. "Method for synthetizing Tebipenem intermediate". Paragraph 0006; 0008. . Retrieved 2016/11/28.