1-methyl-1H-indole-3-carbohydrazide

Base Information

• Chemical Name: 1-methyl-1H-indole-3-carbohydrazide
• CAS No.: 56559-62-7
• Molecular Formula: C10H11N3O
• Molecular Weight: 189.217
• Hs Code.: 2933990090
• European Community (EC) Number: 856-899-2
• DSSTox Substance ID: DTXSID90356124
• Wikidata: Q82135304
• ChEMBL ID: CHEMBL4580287
• Mol file: 56559-62-7.mol

Synonyms:1-methyl-1H-indole-3-carbohydrazide;56559-62-7;1-methylindole-3-carbohydrazide;Oprea1_345963;Oprea1_636278;SCHEMBL6586386;CHEMBL4580287;DTXSID90356124;BBL016232;MFCD02585614;STK349238;AKOS000305718;VS-05233;EN300-13805;1-methyl-1 h-indole-3-carboxylic acid hydrazide;1-Methyl-1H-indole-3-carboxylic acid hydrazide;AN-068/25067029;Z89300755

Chemical Property of 1-methyl-1H-indole-3-carbohydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 60.05000
• Density: 1.3g/cm³
• LogP: 1.87300
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 189.090211983
• Heavy Atom Count: 14
• Complexity: 231

Purity/Quality:

98%min ^*data from raw suppliers

1-methyl-1H-indole-3-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C=C(C2=CC=CC=C21)C(=O)NN

Technology Process of 1-methyl-1H-indole-3-carbohydrazide

There total 11 articles about 1-methyl-1H-indole-3-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethyl 1-methyl-1H-indole-3-carboxylate (56559-60-5) → (1-methyl)indole-3-carboxylic acid hydrazide (56559-62-7)

Guidance literature:

With hydrazine hydrate; In ethylene glycol; at 105 - 110 ℃; for 24h;

Reference yield: 74.0%

methyl 1-methyl-1H-indole-3-carboxylate (108438-43-3) → (1-methyl)indole-3-carboxylic acid hydrazide (56559-62-7)

Guidance literature:

With hydrazine hydrate; In methanol; for 10h; Reflux;

DOI:10.1039/d1nj03892c

Reference yield:

1H-indole-3-carboxylic acid (771-50-6) → (1-methyl)indole-3-carboxylic acid hydrazide (56559-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 20 h / Reflux

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 10 °C / Reflux

2.2: 4 h / 20 °C

3.1: hydrazine hydrate

With sulfuric acid; sodium hydride; hydrazine hydrate; In tetrahydrofuran;

DOI:10.1016/j.ejmech.2012.06.047

upstream raw materials:

ethyl 1-methyl-1H-indole-3-carboxylate

1-methylindole

2,2,2-trichloro-1-(1-methyl-1H-indol-3-yl)ethan-1-one

1-methyl-3-indolecarboxylic acid

Downstream raw materials:

1-benzoyl-2-(N-methylindolecarbonyl)hydrazine

C₂₆H₂₀ClFN₄O

C₂₇H₂₃ClN₄O₂

C₂₇H₂₃FN₄O₂