Indole-3-carboxylic acid, 1-methyl-, ethyl ester

Base Information

• Chemical Name: Indole-3-carboxylic acid, 1-methyl-, ethyl ester
• CAS No.: 56559-60-5
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.241
• Mol file: 56559-60-5.mol

Synonyms:ethyl 1-methylindole-3-carboxylate;3-(N-Methylindolyl)-carbonsaeureethylester;1-methyl-indole-3-carboxylic acid ethyl ester;1-Methyl-indol-3-carbonsaeure-aethylester;

Chemical Property of Indole-3-carboxylic acid, 1-methyl-, ethyl ester

Chemical Property:

• Melting Point: 70-71 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 130-135 °C(Press: 0.01 Torr)
• PSA: 31.23000
• Density: 1.11±0.1 g/cm3(Predicted)
• LogP: 2.35500

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl1-methyl-1H-indole-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Indole-3-carboxylic acid, 1-methyl-, ethyl ester

There total 1 articles about Indole-3-carboxylic acid, 1-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H14INO2 + N'-(4-cyanobenzylidene)-4-methylbenzenesulfonohydrazide (41780-79-4) → ethyl 1-methyl-1H-indole-3-carboxylate (56559-60-5) + C20H18N2O2

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; In acetonitrile; at 110 ℃;

DOI:10.1039/c6cc01880g

Reference yield: 84.0%

ethyl 1-methyl-1H-indole-3-carboxylate (56559-60-5) → (1-methyl)indole-3-carboxylic acid hydrazide (56559-62-7)

Guidance literature:

With hydrazine hydrate; In ethylene glycol; at 105 - 110 ℃; for 24h;

Reference yield:

ethyl 1-methyl-1H-indole-3-carboxylate (56559-60-5) → C27H23FN4O2 (1354714-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol

2: acetic acid / ethanol / Reflux

With hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1016/j.bmcl.2011.11.031

upstream raw materials:

N'-(4-cyanobenzylidene)-4-methylbenzenesulfonohydrazide

Downstream raw materials:

(1-methyl)indole-3-carboxylic acid hydrazide

C₂₇H₂₃FN₄O₂

C₂₆H₂₀ClFN₄O

C₂₇H₂₃ClN₄O₂