2-(4-Methoxyphenyl)-1-methyl-1H-indole-3-carbaldehyde

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-1-methyl-1H-indole-3-carbaldehyde
• CAS No.: 61843-47-8
• Molecular Formula: C17H15NO2
• Molecular Weight: 265.312
• DSSTox Substance ID: DTXSID60493111
• Wikidata: Q82339573
• Mol file: 61843-47-8.mol

Synonyms:2-(4-Methoxyphenyl)-1-methyl-1H-indole-3-carbaldehyde;61843-47-8;SCHEMBL11202452;DTXSID60493111

Chemical Property of 2-(4-Methoxyphenyl)-1-methyl-1H-indole-3-carbaldehyde

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 265.110278721
• Heavy Atom Count: 20
• Complexity: 338

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=CC=CC=C2C(=C1C3=CC=C(C=C3)OC)C=O

Technology Process of 2-(4-Methoxyphenyl)-1-methyl-1H-indole-3-carbaldehyde

There total 13 articles about 2-(4-Methoxyphenyl)-1-methyl-1H-indole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-methyl-2-(4-methoxyphenyl)indole (61843-43-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(4-methoxyphenyl)-1-methyl-1H-indole-3-carbaldehyde (61843-47-8) + 2-(4-methoxyphenyl)-1-methyl-1H-indole-3-carbonitrile (938375-09-8)

Guidance literature:

With oxygen; tetrabutylammonium acetate; palladium diacetate; potassium carbonate; copper(ll) bromide; iron(II) chloride; at 130 ℃; for 24h; under 760.051 Torr;

DOI:10.1021/ja204063z

Reference yield: 74.0%

N-(2-((4-methoxyphenyl)ethynyl)phenyl)-N-methylformamide → 2-(4-methoxyphenyl)-1-methyl-1H-indole-3-carbaldehyde (61843-47-8)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); In acetonitrile; at 90 ℃; for 8h; Inert atmosphere;

DOI:10.1021/ol5024745

Reference yield: 62.0%

(E)-3-(4-methoxyphenyl)-3-(methyl(phenyl)amino)acrylaldehyde → 2-(4-methoxyphenyl)-1-methyl-1H-indole-3-carbaldehyde (61843-47-8)

Guidance literature:

With copper diacetate; palladium diacetate; Trimethylacetic acid; In N,N-dimethyl-formamide; at 120 ℃; Inert atmosphere;

DOI:10.1021/ol5029805

upstream raw materials:

N-methyl-2-(4-methoxyphenyl)indole

N,N-dimethylform-¹³C-amide

N,N-dimethyl-formamide

2-iodo-N-(4-methoxybenzyl)-N-methylaniline