2-(4-methoxyphenyl)-1-methyl-1H-indole

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-1-methyl-1H-indole
• CAS No.: 61843-43-4
• Molecular Formula: C16H15NO
• Molecular Weight: 237.301
• DSSTox Substance ID: DTXSID40355622
• Nikkaji Number: J2.311.143H
• Wikidata: Q82134633
• Mol file: 61843-43-4.mol

Synonyms:2-(4-methoxyphenyl)-1-methyl-1H-indole;2-(4-methoxyphenyl)-1-methylindole;61843-43-4;1H-Indole, 2-(4-methoxyphenyl)-1-methyl-;SCHEMBL3690560;DTXSID40355622;FEPKLFZRXJREBA-UHFFFAOYSA-N;STK256306;AKOS005423674;2-(4-Methoxyphenyl)-1-methyl-1 h-indole;AE-848/05475018

Chemical Property of 2-(4-methoxyphenyl)-1-methyl-1H-indole

Chemical Property:

• PSA: 14.16000
• LogP: 3.85390
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 237.115364102
• Heavy Atom Count: 18
• Complexity: 272

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=CC=CC=C2C=C1C3=CC=C(C=C3)OC

Technology Process of 2-(4-methoxyphenyl)-1-methyl-1H-indole

There total 39 articles about 2-(4-methoxyphenyl)-1-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-methylindole (603-76-9) + 1-(4-Methoxyphenyl)-3,3-diethyl-1-triazene (36719-69-4) → N-methyl-2-(4-methoxyphenyl)indole (61843-43-4)

Guidance literature:

With boron trifluoride diethyl etherate; palladium diacetate; In N,N-dimethyl acetamide; at 80 ℃; for 12h; Sealed tube;

DOI:10.1002/asia.201402274

Reference yield: 93.0%

1-methylindole (603-76-9) + C11H17N3O → N-methyl-2-(4-methoxyphenyl)indole (61843-43-4)

Guidance literature:

With C₉H₁₈N₂O₃S*H₂O₄S; palladium diacetate; In water; N,N-dimethyl-formamide; at 20 ℃; for 5h; Reagent/catalyst; regioselective reaction;

DOI:10.1039/c9nj01728c

Reference yield: 91.0%

2-((4-methoxyphenyl)ethynyl)-N,N-dimethylaniline (62167-04-8) → N-methyl-2-(4-methoxyphenyl)indole (61843-43-4)

Guidance literature:

With ethanol; at 120 ℃; for 10h; Microwave irradiation; Inert atmosphere; Green chemistry;

DOI:10.1039/c9gc01880h

upstream raw materials:

para-iodoanisole

2-lithio-1-methylindole

2-(hydroxydimethylsilyl)-1-methyl-1H-indole

N-acetyl-N-methyl-2-(4-methoxyphenyl)ethynylaniline

Downstream raw materials:

2-(4-Methoxy-phenyl)-3-[(E)-3-[2-(4-methoxy-phenyl)-1-methyl-1H-indol-3-yl]-prop-2-en-(E)-ylidene]-1-methyl-3H-indolium; chloride

3-[(Z)-2-Bromo-3-[2-(4-methoxy-phenyl)-1-methyl-1H-indol-3-yl]-prop-2-en-(E)-ylidene]-2-(4-methoxy-phenyl)-1-methyl-3H-indolium; chloride

3-methoxy-11-methyl-5,6-diphenyl-11H-benzo[a]carbazole

2-(4-methoxyphenyl)-1-methyl-1H-indole-3-carbaldehyde