N-(4-methoxyphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine

Base Information

Chemical Name:N-(4-methoxyphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine
CAS No.:61889-63-2
Molecular Formula:C15H13N3OS
Molecular Weight:283.354
Hs Code.:
DSSTox Substance ID:DTXSID50355193
Wikidata:Q82133926
ChEMBL ID:CHEMBL565911

Synonyms:N-(4-methoxyphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine;61889-63-2;Oprea1_212226;Oprea1_614328;CHEMBL565911;SCHEMBL1889521;DTXSID50355193;VKPSUPZGZYRCSL-UHFFFAOYSA-N;CCG-120112;SDCCGSBI-0141675.P001;Z2718839953

Suppliers and Price of N-(4-methoxyphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-methoxyphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:283.07793322
Heavy Atom Count:20
Complexity:291

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)NC2=NC(=CS2)C3=CC=NC=C3

Technology Process of N-(4-methoxyphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine

There total 4 articles about N-(4-methoxyphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 5349-17-7
4-bromoacetylpyridine hydrobromide

: 2293-07-4
1-(4-methoxyphenyl)thiourea

: 61889-63-2
N-(4-methoxyphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Guidance literature:: 4-bromoacetylpyridine hydrobromide; 1-(4-methoxyphenyl)thiourea; In ethanol; for 1h; Heating; Reflux;

With ammonia; In ethanol; water; at 5 - 20 ℃; for 2h; pH=~ 8;

Reference yield:

: 6221-13-2
4-(bromoacetyl)pyridine

: 2293-07-4
1-(4-methoxyphenyl)thiourea

: 61889-63-2
N-(4-methoxyphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Guidance literature:: 4-(bromoacetyl)pyridine; 1-(4-methoxyphenyl)thiourea; In ethanol; water; at 20 ℃;

With sodium hydroxide; In ethanol; water; at 20 ℃;

Reference yield:

: 1122-54-9
methyl (4-pyridyl) ketone

: 61889-63-2
N-(4-methoxyphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen bromide; bromine; acetic acid / 0 - 75 °C

2.1: ethanol / 1 h / Heating; Reflux

2.2: 2 h / 5 - 20 °C / pH ~ 8

With hydrogen bromide; bromine; acetic acid; In ethanol; 2.1: Hantzsch thiazole synthesis;