6221-13-2

Basic information

• Product Name: 2-BROMO-1-PYRIDIN-4-YLETHANONE
• Synonyms: 2-BROMO-1-PYRIDIN-4-YLETHANONE;Ketone, broMoMethyl pyridin-4-yl;2-broMo-1-(pyridin-4-yl)ethan-1-one;Ethanone, 2-broMo-1-(4-pyridinyl)-;2-Bromo-1-(4-pyridyl)ethanone
• CAS NO: 6221-13-2
• Molecular Formula: C₇H₆BrNO
• Molecular Weight: 200.03
• EINECS: 604-604-1
• Mol File: 6221-13-2.mol
• Article Data: 21

Chemical Properties

• Melting Point: 185-190 °C (decomp)
• Boiling Point: 268.3 °C at 760 mmHg
• Flash Point: 116 °C
• Appearance: /
• Density: 1.57 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.56±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-1-PYRIDIN-4-YLETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-PYRIDIN-4-YLETHANONE(6221-13-2)
• EPA Substance Registry System: 2-BROMO-1-PYRIDIN-4-YLETHANONE(6221-13-2)

Safety Data

• Hazardous Substances Data: 6221-13-2(Hazardous Substances Data)

Usage

General Description

2-BROMO-1-PYRIDIN-4-YLETHANONE is a chemical compound with the molecular formula C7H6BrNO. It is a white to light yellow solid that is commonly used as an intermediate in the pharmaceutical industry for the synthesis of various drugs and pharmaceuticals. It can also be used as a building block in organic synthesis for the production of other chemical compounds. 2-BROMO-1-PYRIDIN-4-YLETHANONE is a highly reactive compound and should be handled with caution, as it can pose a danger to human health and the environment if not properly managed.

Upstream product

• 26377-17-3 ethyl 3-oxo-3-(4-pyridyl)propanoate 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 1570-45-2 isonicotinic acid ethylester 

Downstream Products

• 14898-01-2 4-[2-(4,4'-dimethoxy-benzhydryl)-thiazol-4-yl]-pyridine 
• 30162-43-7 2-(3-Pyridyl)amino-4-(4-pyridyl)thiazol 
• 30235-28-0 4-pyridin-4-yl-thiazol-2-ylamine 
• 316124-45-5 1-pyridin-4-yl-2-(triphenyl-λ⁵-phiosphanylidene)ethanone 
• 118838-55-4 2-bromo-1-(pyridin-4-yl)ethanol 
• 945416-28-4 C₂₅H₃₃N₃O₂ 
• 924883-56-7 2,3-dimethyl-6-pyridin-4-yl-imidazo[2,1-b]thiazole 
• 924884-01-5 2,3-dimethyl-6-pyridin-4-yl-imidazo[2,1-b]thiazole-5-carbaldehyde 
• 14819-33-1 4,4'-(4-pyridin-4-yl-thiazol-2-ylmethanediyl)-bis-phenol 
• 61889-63-2 N-(4-methoxyphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine 
• 892119-40-3 (2-methyl-5-nitro-phenyl)-(5-pyridin-4-yl-lH-imidazol-2-yl)-amine 
• 1084976-06-6 C₁₇H₁₆N₂OS₂ 
• 1084975-97-2 C₁₆H₁₄N₂OS₂ 
• 1104202-16-5 (R)-6-benzyloxymethyl-2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one 

Relevant articles and documents

Synthesis of 2,3-dimethylthio-6-pyridyl tetrathiafulvalene: A precursor for a new system involving a direct linkage between a strong donor (D) and a strong acceptor (A)

A multi-step synthesis of a novel tetrathiafulvalene derivative involving a 4-pyridyl substituent directly attached to the TTF moiety is described.

Design, synthesis, and biological evaluation of urea-based ROCK2 inhibitors

A series of urea-based ROCK2 inhibitors were design and synthesized. The inhibitory activity on ROCK2 was screened by enzyme-linked immunosorbent assay (ELISA). The study results showed that the urea derivatives exhibited certain ROCK2 inhibitory activity. The most potent compound 10p showed ROCK2 inhibitory activity with the IC50?value of 0.03?μM. A preliminary structure-activity relationship was then summarized. The molecular docking studies showed that further optimization needs to conduct to obtain more potent ROCK inhibitors.

SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS

Substituted pyrazolo[4,3-b]pyridines as GluN2B receptor ligands. Such compounds may be used in GluN2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by GluN2B rece